基本信息
浏览量:70
职业迁徙
个人简介
Ivan Zanoni laboratory studies innate immune cell biology as a means of understanding the earliest events that initiate immunity to infection or drive the development of immune-mediated diseases. He focused primarily on the study of Pattern Recognition Receptor (PRR) signaling pathways. PRRs initiate all immune responses and activate a network of transcription factors that orchestrate the inflammatory response. The organizing principles that govern PRR signaling are largely unknown and their elucidation will likely answer several fundamental questions about the pathophysiological development of the inflammatory process. His work established the first example of a cellular response to bacterial lipopolysaccharide (LPS) that does not depend on Toll-like Receptor (TLR)4, the prototype of the TLRs that are the best characterized family of PRRs. It has long been dogma that signaling via TLR4 is the only means by which mammalian cells respond to LPS. Ivan Zanoni uncovered that CD14 controls the LPS-induced endocytosis of TLR4, a process that is critical for the signaling functions of this receptor in numerous mammalian cell types. He also found that dendritic cells respond to LPS in a TLR4-independent manner that is important for regulating the activation of the Nuclear Factor of Activated T cells (NFAT). This work blurred the line between innate and adaptive immunity, and documented that NFAT operates in cells of both types of immunity. His findings that TLR4-independent LPS response pathway exists and that CD14 has autonomous signaling capacity open new perspectives on the study of LPS-driven inflammatory diseases and, in general, on the potential of co-receptors to modify and integrate the immune responses elicited by their cognate receptor. Goals of Dr. Zanoni’s research include: Understanding the molecular mechanisms that govern the cross-talk between co-receptors and their cognate receptors; Understanding how NFAT activation in innate immune cells regulates the inflammatory process; Understanding how PRRs signaling contributes to the development of inflammatory diseases and metabolic disorders.
研究兴趣
论文共 167 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Antonio E. Pontiroli, Francesco Scovenna,Valentina Carlini,Elena Tagliabue,Jimmy Martin-Delgado,Lucia La Sala, Elisabetta Tanzi,Ivan Zanoni
Current Opinion in Immunology (2024): 102423-102423
IJID REGIONS (2024)
Dania Zhivaki,Stephanie N. Kennedy, Josh Park,Francesco Boriello,Pascal Devant,Anh Cao,Kristin M. Bahleda, Shane Murphy,Cristin McCabe,Charles L. Evavold, Kate L. Chapman,Ivan Zanoni,Orr Ashenberg,Ramnik J. Xavier,Jonathan C. Kagan
Cell (2024)
Thais Boccia, Weikang Pan,Victor Fattori, Rodrigo Cervantes-Díaz,Michael S. Rogers,Ivan Zanoni, Alex G. Cuenca
crossref(2024)
NATURE METABOLISMno. 5 (2024): 779-782
加载更多
作者统计
#Papers: 167
#Citation: 8018
H-Index: 42
G-Index: 88
Sociability: 7
Diversity: 0
Activity: 2
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn