基本信息
浏览量:2
职业迁徙
个人简介
We use Drosophila and mammalian neural stem cells (NSCs) to model neurodevelopmental disorders and brain tumours.
NSCs are crucial for the development, regeneration, and repair of the nervous system. The delicate balance between NSC quiescence and activation is important for adult neurogenesis and NSC maintenance. We and others are establishing Drosophila NSCs as a model system to elucidate the disease mechanisms underlying neurodevelopmental disorders. Currently, we are interested in addressing the following key questions: What are the intrinsic mechanisms underlying NSC reactivation? What are the molecular signatures of quiescent NSCs? What are the extrinsic signals “waking up” quiescent NSCs?
We and others have established Drosophila larval brain neural stem cells as a model for stem cell self-renewal and tumorigenesis. Our work demonstrated a causal link between deficits in NSC asymmetric division and the formation of brain tumours in Drosophila models. Currently, we are interested in addressing the following key questions: What mutations trigger neural stem cells to become cancer stem cells? How asymmetric divisions of neural stem cells are regulated? What are the mechanisms that prevent more mature cells from dedifferentiating back into neural stem cells?
Prod. Wang is an elected EMBO Associate Member (2020), recipient of the Singapore National Academy of Science Young Scientist Award (2008), and the National Research Foundation (NRF) Research Fellowship (2009-2014). She is Associate Editor of PLOS Genetics and Genetics; Asia-Pacific Drosophila Board member, the founding president of Society of Developmental Biologists Singapore, and executive member of Stem Cell Society Singapore.
NSCs are crucial for the development, regeneration, and repair of the nervous system. The delicate balance between NSC quiescence and activation is important for adult neurogenesis and NSC maintenance. We and others are establishing Drosophila NSCs as a model system to elucidate the disease mechanisms underlying neurodevelopmental disorders. Currently, we are interested in addressing the following key questions: What are the intrinsic mechanisms underlying NSC reactivation? What are the molecular signatures of quiescent NSCs? What are the extrinsic signals “waking up” quiescent NSCs?
We and others have established Drosophila larval brain neural stem cells as a model for stem cell self-renewal and tumorigenesis. Our work demonstrated a causal link between deficits in NSC asymmetric division and the formation of brain tumours in Drosophila models. Currently, we are interested in addressing the following key questions: What mutations trigger neural stem cells to become cancer stem cells? How asymmetric divisions of neural stem cells are regulated? What are the mechanisms that prevent more mature cells from dedifferentiating back into neural stem cells?
Prod. Wang is an elected EMBO Associate Member (2020), recipient of the Singapore National Academy of Science Young Scientist Award (2008), and the National Research Foundation (NRF) Research Fellowship (2009-2014). She is Associate Editor of PLOS Genetics and Genetics; Asia-Pacific Drosophila Board member, the founding president of Society of Developmental Biologists Singapore, and executive member of Stem Cell Society Singapore.
研究兴趣
论文共 89 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Dongliang Ma, Kun-Yang Lin, Divya Suresh,Jiaen Lin,Mahekta R. Gujar, Htet Yamin Aung,Ye Sing Tan,Yang Gao, Anselm S. Vincent,Teng Chen,Hongyan Wang
PLOS BIOLOGYno. 8 (2024)
Crop Protectionpp.107032, (2024)
FREE RADICAL BIOLOGY AND MEDICINE (2024): 63-76
International Journal of Molecular Sciencesno. 2 (2024): 827-827
Muhammad Abdelbasset, Wilfried A.A. Saron, Dongliang Ma, Abhay P.S. Rathore, Tatsuya Kozaki, Chengwei Zhong, Chinmay Kumar Mantri, Yingrou Tan, Chi-Ching Tung, Hong Liang Tey,Justin Jang Hann Chu,Jinmiao Chen,Lai Guan Ng,Hongyan Wang,Florent Ginhoux, Ashley L. St. John
Cell (2024)
SCIENCE ADVANCESno. 30 (2024)
Oxford open neuroscience (2023): kvac017-kvac017
TOXICOLOGY (2023)
加载更多
作者统计
#Papers: 88
#Citation: 2946
H-Index: 29
G-Index: 54
Sociability: 6
Diversity: 3
Activity: 43
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn