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个人简介
The Sesaki laboratory is interested in the molecular mechanisms and physiological roles of mitochondrial fusion and division. Mitochondria are highly dynamic and control their morphology by a balance of fusion and division. The regulation of membrane fusion and division generates a striking diversity of mitochondrial shapes, ranging from numerous small spheres in hepatocytes to long branched tubules in myotubes. In addition to shape and number, mitochondrial fusion is critical for normal organelle function. For example, mice that are defective in mitochondrial fusion die during early development while yeast fusion mutants rapidly lose their mitochondria genome and become incapable of oxidative phosphorylation. Moreover, mitochondrial fusion also regulates the release of cytochrome C during apoptosis. Therefore, it is not surprising that defects in mitochondrial fusion cause neurodegenerative disorders in humans, including Charcot-Marie-Tooth disease type 2A and autosomal dominant optic atrophy.
Using yeast as a model system, the lab has identified several components that mediate and regulate mitochondrial fusion. The lab is currently trying to determine their functions in both yeast and mammals. The goals of this research are to understand the molecular basis of mitochondrial fusion and division using biochemical approaches and to determine the physiological roles of mitochondrial fusion using cell culture and animal models.
Using yeast as a model system, the lab has identified several components that mediate and regulate mitochondrial fusion. The lab is currently trying to determine their functions in both yeast and mammals. The goals of this research are to understand the molecular basis of mitochondrial fusion and division using biochemical approaches and to determine the physiological roles of mitochondrial fusion using cell culture and animal models.
研究兴趣
论文共 188 篇作者统计合作学者相似作者
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Natureno. 8027 (2024): 1110-1117
Daisuke Murata, Fumiya Ito,Gongyu Tang, Wakiko Iwata, Nelson Yeung, Junior J West,Andrew J Ewald,Xiaowei Wang,Miho Iijima,Hiromi Sesaki
iScienceno. 9 (2024): 110880-110880
iScienceno. 6 (2024): 109874-109874
PHYSIOLOGY (2024)
Xin Li, Katherine Pham, Jazmin Ysaguirre,Iqbal Mahmud,Lin Tan, Bo Wei, Long J Shao,Maryam Elizondo, Rabie Habib, Fathima Elizondo,Hiromi Sesaki,Philip L Lorenzi,Kai Sun
Journal of lipid researchno. 9 (2024): 100633-100633
Developmental Cell (2024)
Vedavathi Madhu, Miriam Hernandaz-Meadows,Ashley Coleman,Kimheak Sao, Kameron Inguito, Owen Haslam,Paige K Boneski,Hiromi Sesaki,John A Collins,Makarand V. Risbud
bioRxiv the preprint server for biology (2024)
Makarand Risbud,Vedavathi Madhu,Miriam Hernandez-Meadows,Ashley Coleman,Kimheak Sao, Kameron Inguito, Owen Haslam,Paige Boneski,Hiromi Sesaki,John Collins
Research square (2024)
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作者统计
#Papers: 188
#Citation: 12209
H-Index: 58
G-Index: 109
Sociability: 7
Diversity: 0
Activity: 2
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