He has contributed particularly to researches on pathogeneses of ALS, Pure Akinesia/PSP, SCA, mitochondrial neuropathy, distal myopathy and Prion disease.He has long been Chairpersons of Research Committees on Prion disease, Ministry of Health, Welfare and Labor, Japan (2002 – 2011) and on Surveillance and Control of Prion Disease and Surveillance (2010 – 2020).He has been core members of Research Committees on Neurodegenerative Diseases and on Ataxic Disorders of which he was appointed as Chairperson (2014 – 2020).He has been also a member of Advisory Board of National SCA/MSA Patients’ Association. Regarding the Initiative on Rare and Undiagnosed Disease, he has been the PI since 2015.He served as President of Japanese Society of Neurology (2010 – 2014) and was President of PRION 2016 in Tokyo, President of WCN 2017 in Kyoto and Vice President of ICN 2018 in Tokyo.