基本信息
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职业迁徙
个人简介
Research interests
My overarching research focus is to understand how immune activation is linked to heart disease. Following a severe infection like pneumonia, individuals are at a higher risk of heart attack or stroke for up to 3 weeks after the infection.
We believe this is because immune cells in the atherosclerotic plaque become activated by inflammation, making the plaque more prone to rupture. Macrophages are a key immune cell in the arterial plaque, that alter their response and cellular function when exposed to infection or inflammatory signals.
We have investigated how these atherosclerotic macrophages alter functionally according to their environment. Specifically we have addressed how P2X7 receptors, interleukin-1 secretion and Tribbles expression affect macrophage function.
We are currently also interested in understanding the function of adipose tissue macrophages, since different fat depots are more or less associated with inflammation and disease: abdominal fat is associated with cardiovascular diseases and cancer susceptibility, while peripheral fat confers a lower disease risk.
We work closely with cardiology and stroke consultants within IICD and the Medical School in Sheffield so that our basic science is connected to patient disease. We are also fortunate to be part of a European Commission funded International Training Network, where we connect with scientists across Europe who have complimentary interests to link immunity, metabolism and disease together. We are increasingly aware that obesity is connected to cancer risk as well as cardiovascular diseases, and seek to understand the underlying mechanisms.
研究兴趣
论文共 293 篇作者统计合作学者相似作者
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Kezia R. Fourie, Alison Jeffery, Dylan Chand,Pooja Choudhary, Siew Hon Ng, Haoming Liu, Donaldson Magloire, Zahed Khatooni, Emil Berberov,Heather L. Wilson
Vaccineno. 24 (2024): 126254-126254
Charlotte E. Moss,Simon A. Johnston, Joshua V. Kimble, Martha Clements,Veryan Codd,Stephen Hamby,Alison H. Goodall,Sumeet Deshmukh,Ian Sudbery,Daniel Coca,Heather L. Wilson,Endre Kiss-Toth
Cell reportsno. 4 (2024): 114073-114073
Neve E Read,Heather M Wilson
International Journal of Molecular Sciencesno. 13 (2024): 7207
Aarushi Singhal, Umesh Dhawan, Kunzangla Bhutia,Heather Wilson, Guillermo Velasco,Endre Kiss-Toth, Manikandan Subramanian
Atherosclerosis (2024): 118481
Karolína Steinerová,John C. S. Harding,Sarah E. Parker,Heather L. Wilson, Arthur Nery Finatto,Yolande M. Seddon
Frontiers in Veterinary Science (2024)
Neurologypp.603-654, (2024)
Frontiers in immunology (2023): 1171212
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作者统计
#Papers: 293
#Citation: 8890
H-Index: 52
G-Index: 84
Sociability: 7
Diversity: 4
Activity: 72
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