基本信息
浏览量:210
职业迁徙
个人简介
Our research activities center on the molecular genetics and biology of cancer with a focus on the identification, characterization, and therapeutic targeting of driver mutations involved in the genesis and progression of brain cancers. Gliomas are the most common type of primary brain tumor. Through genomic studies, we have identified mutations in IDH1 and IDH2 in 70% of progressive malignant gliomas. These are somatic missense mutations that alter a conserved arginine residue and gain a neomorphic activity. A new metabolite produced by the glioma cells impacts on chromatin modulation and genome methylation. Malignant cells must maintain their telomeres. We identified several different tumor types exhibiting a high frequency of TERT promoter mutations, including several glioma subtypes. Conversely, we found a low frequency of TERT promoter mutations in many common epithelial tumors. In gliomas, we found that TERT promoter mutations were mutually exclusive with ATRX alterations, which are associated with activation of the ALT pathway for telomere maintenance. These findings show that TERT promoter mutations are frequent driver events in many human cancers, particularly those that arise from tissues with low rates of self-renewal. Our long-term goal is to develop a novel molecular-based glioma classification system and a targeted therapy on the basis of IDH1 and TERT mutations. To provide novel avenues for development of anticancer therapeutics, studies involving cell line and animal models, enzymatic study, metabolome and epigenome, are being investigated to determine the consequences of IDH1 and TERT mutations on cancer cells.
研究兴趣
论文共 264 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yibo Gao,Dandan Cao, Mengfan Li,Fuqiang Zhao, Pei Wang,Shiwen Mei,Qianqian Song, Yanli Nie,Wei Zhao,Sizhen Wang,Hai Yan,Xishan Wang,Yuchen Jiao,Qian Liu
Molecular cancerno. 1 (2024): 173-173
openalex(2023)
Junbo Liang,Hong Zhao,Bill H. Diplas,Song Liu, Jianmei Liu, Dingding Wang, Yan Lu,Qing Zhu,Jiayu Wu,Wenjia Wang,Hai Yan,Yi-Xin Zeng,Xiaoyue Wang,Yuchen Jiao
openalex(2023)
Kathryn Gunn,Matti Myllykoski,John Z. Cao, Manna Ahmed,Bofu Huang,Betty Rouaisnel,Bill H. Diplas,Michael M. Levitt,Ryan Looper,John G. Doench,Keith L. Ligon,Harley I. Kornblum,Samuel K. McBrayer,Hai Yan, Cihangir Duy, Lucy A. Godley, Peppi Koivunen,Julie-Aurore Losman
openalex
crossref(2023)
crossref(2023)
crossref(2023)
Christopher J. Pirozzi,Austin B. Carpenter,Matthew S. Waitkus, Catherine Y. Wang,Huishan Zhu,Landon J. Hansen,Lee H. Chen,Paula K. Greer, Jiashi Feng,Yu Wang,Cheryl B. Bock,Ping Fan,Ivan Spasojević,Roger E. McLendon,Darell D. Bigner,Yiping He,Hai Yan
openalex(2023)
加载更多
作者统计
#Papers: 264
#Citation: 35270
H-Index: 68
G-Index: 187
Sociability: 7
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn