Dr. Hung Nguyen is an Assistant Professor of Medicine in College of Medicine at the University of Central Florida. He has a tremendous interest in understanding how cell metabolism decides T-cell fate and function in COVID-19, hematopoietic stem cell transplantation, adoptive T-cell transfer therapy, and autoimmune diseases. Dr. Nguyen received his BSc from Hanoi University of Pharmacy in Vietnam. He then earned a PhD in Biochemistry at Chungnam National University in Korea. He began the postdoctoral training on hematopoietic stem cell transplantation and cancer immunology at Medical University of South Carolina. He found that T-cells metabolically reprogram after allogeneic bone marrow stem cell transplantation. He started his lab at the University of Central Florida in August 2019 with an extensive scientific program in immunotherapy. His lab located at Lake Nona Campus. Nguyen Lab studies the integration of metabolism and T-cell biology. Specifically, his research is to understand how metabolism regulates T-cell auto/allo-reactivity in autoimmune diseases, transplantation, and cancers. It has now become apparent that metabolism is a key factor regulating T-cell response. Pathogenic T-cells possess distinct metabolic profiles in different immunological disorders. Main lines of research in Nguyen Lab will be translating knowledge of metabolism into therapeutic treatment of COVID-19, autoimmune disease, transplant rejection, and Graft-versus-Host Disease. T-cells and cancer cells are well known for competing for nutrients in tumor microenvironment. In this regard, Nguyen Lab will be focusing on targeting nutrient sensing and metabolism to improve the efficacy of cancer immunotherapy.