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Career Trajectory
Bio
Having developed a program in breast cancer research, Dr. Koeffler is looking at the molecular causes and novel forms of therapy of the disease. He has secured NIH grant and US Army grant funding for breast cancer. Dr. Koeffler has developed a program in prostate cancer research and is looking at novel forms of therapy. He has begun a clinical trial of 9-cis retinoic acid in the disease. He has secured NIH funding as wellas private philanthropic sources for prostate cancer. Leukemias, preleukemias and lymphomas: Studying the basic biology of these diseases and developing novel forms of therapy including vaccines. He has NIH funding that is used for this research. Dr. Koeffler has cloned a pivotal hematopoietic control gene known asC\EBPs, and now making transgenic and "knockout" mice to define the in vivo activities of this gene. He anticipates writing a major NIH grant for this work. Program of cloning new genes: Dr. Koeffler has recently cloned a cyclinA1 gene and a protein processing gene using molecular biology and genetic techniques, and he is now defining the biology of these genes and their implications to cancer development. He has established a research team that uses computers, data banks and gene libraries to clone rapidly novel, interesting genes. Identification of novel tumor suppressor genes using extensive tumor DNA banks from over twenty tumor types with matched normal control DNA from the same individual and using over 300 microsatellites. Dr. KoefflerÂs group is sublocalizing the site of tumor suppressor genes that are mutated in a variety of cancers. This study is funded in part by the Concern Foundation.
Research Interests
Papers共 1319 篇Author StatisticsCo-AuthorSimilar Experts
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Kelly Ooi Kee Ong,Michelle Meng Huang Mok,Akiko Niibori-Nambu,Linsen Du,Masatoshi Yanagida,Chelsia Qiuxia Wang,Avinash Govind Bahirvani,Desmond Wai Loon Chin,Cai Ping Koh,King Pan Ng,Namiko Yamashita,Bindya Jacob,Tomomasa Yokomizo,Hitoshi Takizawa,Takayoshi Matsumura,Toshio Suda,Jie-ying Amelia Lau,Tuan Zea Tan,Seiichi Mori,Henry Yang,Masayuki Iwasaki,Takashi Minami,Norio Asou,Qiao-Yang Sun,Ling-Wen Ding,H. Phillip Koeffler,Daniel G. Tenen,Ritsuko Shimizu,Masayuki Yamamoto,Yoshiaki Ito,Shirley Kow Yin Kham,Allen Eng-Juh Yeoh,Wee Joo Chng,Motomi Osato
EXPERIMENTAL HEMATOLOGY (2024)
Frances Kusuma,Aishvaryaa Prabhu, Galen Tieo, Syed Moiz Ahmad,Pushkar Dakle,Wai Khang Yong,Elina Pathak,Vikas Madan,Yan Yi Jiang,Wai Leong Tam,Dennis Kappei,Peter Dröge,H. Phillip Koeffler,Maya Jeitany
Cancer Researchno. 8_Supplement (2024)
Frances Karla Kusuma,Aishvaryaa Prabhu, Galen Tieo,Syed Moiz Ahmed,Pushkar Dakle,Wai Khang Yong,Elina Pathak,Vikas Madan,Yan Yi Jiang,Wai Leong Tam,Dennis Kappei,Peter Dröge,H. Phillip Koeffler,Maya Jeitany
International Journal of Biological Sciencesno. 8 (2024): 3140-3155
ADVANCED SCIENCEno. 9 (2024)
Yuan Jiang,Yueyuan Zheng,Yuan-Wei Zhang, Shuai Kong,Jinxiu Dong,Fei Wang,Benjamin Ziman,Sigal Gery,Jia-Jie Hao,Dan Zhou, Jianian Zhou,Allen S. Ho,Uttam K. Sinha,Jian Chen, Shuo Zhang,Chuntong Yin,Dan-Dan Wei,Masaharu Hazawa,Huaguang Pan,Zhihao Lu,Wen-Qiang Wei,Ming-Rong Wang,H. Phillip Koeffler,De-Chen Lin,Yan-Yi Jiang
NATURE COMMUNICATIONSno. 1 (2024)
Masaharu Hazawa,Dini Kurnia Ikliptikawati,Yuki Iwashima,De-Chen Lin,Yuan Jiang,Yujia Qiu,Kei Makiyama,Koki Matsumoto,Akiko Kobayashi,Goro Nishide,Lim Keesiang, Hironori Yoshino,Toshinari Minamoto,Takeshi Suzuki,Isao Kobayashi,Makiko Meguro-Horike,Yan-Yi Jiang,Takumi Nishiuchi,Hiroki Konno,H. Phillip Koeffler,Kazuyoshi Hosomichi,Atsushi Tajima,Shin-ichi Horike,Richard W. Wong
CELL CHEMICAL BIOLOGYno. 4 (2024)
Rong Wang, Yu Pan, Lan Zhang,Jun Wang,Jiang Ni,Yang Ding, Shaopeng Wang,Jian Yin,Lingwen Ding,Xuebin Ran,Shuangyi Fan,Qiaoyang Sun,Soo Yong Tan,H. Phillip Koeffler,Jie Li,Yuanyuan Mi,Yong Q. Chen
International Journal of Biological Macromoleculespp.134844-134844, (2024)
crossref(2024)
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Author Statistics
#Papers: 1320
#Citation: 76554
H-Index: 134
G-Index: 228
Sociability: 8
Diversity: 0
Activity: 3
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