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The primary objective of my research is to develop sensitive and specific methods for the determination of well-known or suspected "endocrine disrupting chemicals" in human blood and urine samples of individuals exposed at the workplace or via the environment. Particular focus is on phthalates (e.g. DEHP, DBP, DINP, etc.) and their substitutes (DINCH, terephthalates, adipates), non-persistent pesticides and fungizides (e.g. organophosphorus compounds, pyrethoids, vinclozoline, etc.), UV-filters and solvents by using 2-dimensional high performance liquid chromatography and tandem mass spectrometry (LC-MS/MS) as well as metals (e.g. cadmium and manganese) employing atomic absorption spectroscopy or ICP-MS. Particular focus is also on the metabolism and elimination kinetics of these compounds in-vivo. For this purpose, stable isotope labelled compounds are ingested by volunteers or in animal experiments and blood and urine are subsequently analysed for suspected metabolites. Overall aim is to identify appropriate biomarkers of exposure which in turn can be used in larger-scale molecular epidemiological studies to provide additional data for risk assessment in humans, in particular possible susceptible subgroups such as children and persons in reproductive age. Finally, the data can be used to identify causal relationships between exposure and endocrine effects in humans.
The primary objective of my research is to develop sensitive and specific methods for the determination of well-known or suspected "endocrine disrupting chemicals" in human blood and urine samples of individuals exposed at the workplace or via the environment. Particular focus is on phthalates (e.g. DEHP, DBP, DINP, etc.) and their substitutes (DINCH, terephthalates, adipates), non-persistent pesticides and fungizides (e.g. organophosphorus compounds, pyrethoids, vinclozoline, etc.), UV-filters and solvents by using 2-dimensional high performance liquid chromatography and tandem mass spectrometry (LC-MS/MS) as well as metals (e.g. cadmium and manganese) employing atomic absorption spectroscopy or ICP-MS. Particular focus is also on the metabolism and elimination kinetics of these compounds in-vivo. For this purpose, stable isotope labelled compounds are ingested by volunteers or in animal experiments and blood and urine are subsequently analysed for suspected metabolites. Overall aim is to identify appropriate biomarkers of exposure which in turn can be used in larger-scale molecular epidemiological studies to provide additional data for risk assessment in humans, in particular possible susceptible subgroups such as children and persons in reproductive age. Finally, the data can be used to identify causal relationships between exposure and endocrine effects in humans.
Research Interests
Papers共 299 篇Author StatisticsCo-AuthorSimilar Experts
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Antje Gerofke,Rosa Lange,Nina Vogel,Phillipp Schmidt,Till Weber,Madlen David,Hanne Frederiksen,Kirsten Baken,Eva Govarts,Liese Gilles,Laura Rodriguez Martin,Zanna Martinsone,Tiina Santonen,Greet Schoeters,Martin Scheringer,Elena Dominguez-Romero,Marta Esteban Lopez,Argelia Castano Calvo,Holger M. Koch,Petra Apel,Marike Kolossa-Gehring
International journal of hygiene and environmental health (2024): 114378-114378
TOXICOLOGY LETTERS (2024): 104-112
FRONTIERS IN PUBLIC HEALTH (2024): 1321138-1321138
ARCHIVES OF TOXICOLOGYno. 5 (2024): 1383-1398
Nancy B. Hopf, Helene P. De Luca,Myriam Borgatta,Holger M. Koch,Claudia Paelmke, Manon Benedetti,Aurelie Berthet,Elena Reale
Environment International (2024)
Isabell Schoenrath,Christoph Schmidtkunz,Katharina E. Ebert,Katja Kuepper,Thomas Bruening,Holger M. Koch,Gabriele Leng
Toxicology letters (2024)
Mercè Garí,Daniel Bury,Rebecca K. Moos, Monika Wolniewicz,Agnieszka Jankowska, Agnieszka Brzozowska,Joanna Jerzynska, Stephan Bose-O’Reilly,Holger M. Koch, Kinga Polanska
Exposure and Healthpp.1-10, (2024)
Talanta (2024): 124974-124974
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Author Statistics
#Papers: 299
#Citation: 13209
H-Index: 61
G-Index: 107
Sociability: 8
Diversity: 0
Activity: 2
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