基本信息
浏览量:46
职业迁徙
个人简介
Research interests
Healthy aging
Alzheimer's Disease and Dementia
Centenarians
Resilience against cognitive decline
Resistance against cognitive decline
Genetics
Genetics of Neurodegenerative Disease
100-plus Study
Reaching extreme ages with maintained cognitive function runs in families, suggesting that the genome is involved. To investigate the ‘protective genome’ and derivative cellular constellations, we have set upt the 100-plus Study (www.100plus.nl), a longitudinal cohort study of cognitively healthy centenarians. Currently the cohort includes >400 centenarians from whom we collect brain tissues, blood samples, DNA samples, and feces samples. This cohort has thus far provided a wealth of new insights into how these individuals maintained their cognitive health: we observed an enrichment of protective genetic elements, which may underlie the resistance or resilience against accumulation of specific neuropathological substrates we observed in their brains.
研究兴趣
论文共 160 篇作者统计合作学者相似作者
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Desiree D. S. H. de Bruin,Martin A. Haagmans,Kristiaan J. van der Gaag,Jerry Hoogenboom,Natalie E. C. Weiler,Niccolo Tesi,Alex Salazar, Yaran Zhang,Henne Holstege,Marcel Reinders, Amade Aouatef M'charek,Titia Sijen,Peter Henneman
FORENSIC SCIENCE INTERNATIONAL-GENETICS (2025)
Sven J. van der Lee,Marc Hulsman,Rosalina M.L. van Spaendonk,Jetske van der Schaar,Janna I.R. Dijkstra,Niccoló Tesi,Fred van Ruissen,Mariet W. Elting,Marcel T. Reinders,Itziar de Rojas,Corien Verschuuren,Wiesje M. van der Flier, Mieke M. van Haelst, Christa M. de Geus,Yolande A.L. Pijnenburg,Henne H. Holstege
medrxiv(2024)
Janna Dijkstra,Lisa Vermunt,Vikram Venkatraghavan, Georgii Ozgehov,Emma M. Coomans,Rik Ossenkoppele,Elsmarieke van de Giessen,Marc Hulsman, Christa M. de Geus,Wiesje M. van der Flier,Sietske A.M. Sikkes,Frederik Barkhof,Betty Tijms,Alida A. Gouw, Willem de Haan,Everard G.B. Vijverberg,Yolande A.L. Pijnenburg,Henne Holstege, Charlotte E. Teunissen, Sven J. van der Lee
crossref(2024)
Betty M. Tijms,Ellen M. Vromen,Olav Mjaavatten,Henne Holstege,Lianne M. Reus,Sven van der Lee,Kirsten E. J. Wesenhagen,Luigi Lorenzini,Lisa Vermunt,Vikram Venkatraghavan,Niccoló Tesi,Jori Tomassen,Anouk den Braber,Julie Goossens,Eugeen Vanmechelen,Frederik Barkhof,Yolande A. L. Pijnenburg,Wiesje M. van der Flier,Charlotte E. Teunissen,Frode S. Berven,Pieter Jelle Visser
NATURE AGINGno. 1 (2024)
Audrey Coulon, Florian Rabiller,Mari Takalo,Avishek Roy,Henna Martiskainen,Dolores Siedlecki-Wullich,Tiago Mendes, Celia Lemeu, Lukas-Iohan Carvalho, Anaël Ehrardt,Ana Raquel Melo de Farias,Marc Hulsman,Chloé Najdek, Nina Lannette-Weimann, Alejandra Freire-Regatillo,Philippe Amouyel,Camille Charbonnier, Orio Dols-Icardo,Heli Jeskanen,Roosa-Maria Willman,Teemu Kuulasmaa,Mitja Kurki,John Hardy, Richard Wagner,Sami Heikkinen,Henne Holstege,Petra Mäkinen,Gaël Nicolas,Simon Mead,Michael Wagner,Alfredo Ramirez,Tuomas Rauramaa,Aarno Palotie,Rebecca Sims,Hilkka Soininen,John van Swieten,Julie Williams,Céline Bellenguez,Benjamin Grenier-Boley, Carla Gelle,Erwan Lambert,Anne-Marie Ayral,Florie Demiautte,Marcos R. Costa,Séverine Deforges,Devrim Kilinc,Christophe Mulle,Julien Chapuis,Mikko Hiltunen,Julie Dumont,Jean-Charles Lambert
biorxiv(2024)
Niccoló Tesi,Alex Salazar, Yaran Zhang,Sven van der Lee,Marc Hulsman,Lydian Knoop,Sanduni Wijesekera,Jana Krizova, Anne-Fleur Schneider,Maartje Pennings,Kristel Sleegers,Erik-Jan Kamsteeg,Marcel Reinders,Henne Holstege
Genome researchno. 11 (2024): 1942-1953
Baayla D. C. Boon,Irene Frigerio, Danae de Gooijer,Tjado H. J. Morrema, John Bol,Yvon Galis de Graaf,Martijn Heymans,Melissa E. Murray,Sven J. van der Lee,Henne Holstege, Wilma D. J. van de Berg,Laura E. Jonkman,Annemieke J. M. Rozemuller,Femke H. Bouwman,Jeroen J. M. Hoozemans
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGYno. 5 (2024)
ALZHEIMERS & DEMENTIAno. 6 (2024): 3864-3875
Luigi Lorenzini,Lyduine E. Collij,Niccolo Tesi,Natalia Vilor-Tejedor,Silvia Ingala,Kaj Blennow,Christopher Foley,Giovanni B. Frisoni,Sven Haller,Henne Holstege, Van Der,Pablo Martinez-Lage,Riccardo E. Marioni,Daniel L. McCartney,John O' Brien,Tiago Gil Oliveira,Pierre Payoux,Marcel Reinders,Craig Ritchie,Philip Scheltens,Adam J. Schwarz,Carole H. Sudre,Adam D. Waldman,Robin Wolz, Gael Chatelat,Michael Ewers,Alle Meije Wink,Henk J. M. M. Mutsaerts,Juan Domingo Gispert,Pieter Jelle Visser,Betty M. Tijms,Andre Altmann,Frederik Barkhof
ALZHEIMERS & DEMENTIA (2024)
Genome research (2024)
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作者统计
#Papers: 160
#Citation: 5227
H-Index: 34
G-Index: 72
Sociability: 7
Diversity: 2
Activity: 89
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