Our research focusses on obtaining a better understanding and define biomarkers of the phenomenon of immuno-senescence during ageing. Because of immuno-senescence, which is defined as a state of reduced functioning of the immune system, older adults become more susceptible to infections like those caused by influenza viruses and respiratory syncytial virus (RSV). Therefore, older adults are at higher risk for these infections and vaccination against some of these infections is recommended for this age group.

However, because of immuno-senescence, older adults may not respond as well compared to younger subjects and one of the aims of our research is to develop strategies to temporarily overcome immuno-senescence to improve vaccine-induced immune responses in elderly subjects. Potentially, this may also apply for the use of future vaccines that are currently being developed against COVID-19, which is more severe and often fatal in older adults.