基本信息
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Bio
从2001年开始,课题组就进行死亡受体功能的系列研究,实验室主要集中在肿瘤免疫及自身免疫性疾病方面,研究靶点为死亡受体DR5,我们获得多株抗DR5单克隆抗体以及抗人死亡受体5的单链抗体。从2010年开始课题组将TIPE家族结合到相关研究中,我们发现在天然免疫中 TIPE2在TLR途径中通过PI3K-Rac通路调控细胞因子的分泌;在心脏异位移植中,TIPE2在移植心脏中表达上调与移植心脏的免疫细胞浸润及凋亡密切相关;我们研究还发现胃癌临床标本中,ERK、DcR3与TIPE在胃癌组织高表达,TIPE与ERK1有相关性,与DcR3的分泌相关;在RA研究中我们研究发现TIPE2在 RA FLS表达下调,并且抵抗凋亡促进炎性细胞因子的分泌。
Research Interests
Papers共 101 篇Author StatisticsCo-AuthorSimilar Experts
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Xiaole Meng,Risi Na,Xiao Peng,Hui Li,Wanxin Ouyang,Wenting Zhou,Xuting You, Yuhuan Li,Xin Pu, Ke Zhang,Junjie Xia,Jie Wang,
Xiaole Meng,Xiao Peng,Wanxin Ouyang,Hui Li,Risi Na,Wenting Zhou,Xuting You, Yuhuan Li, Xin Pu, Ke Zhang,Junjie Xia, Jie Wang,
Clinical Immunology (2023): 109636-109636
Nengneng Li, Sheng Xu,Shuaishuai Zhang,Qiang Zhu,Xiaole Meng,Wenbin An,Baoqing Fu, Min Zhong,Yan Yang,Zeyang Lin,Xueni Liu,Junjie Xia,
Frontiers in Immunology (2023)
Mengya Zhong, Zhijian Chen,Yang Yan, Argen Bahet, Xin Cai,Huiyu Chen,Honggang Ran,Kaiyong Qu,Zhaopu Han,Guohong Zhuang,Shifeng Zhang,Yinan Wang
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