He is widely published as a researcher focusing on the delineation, effects and treatment of pediatric/developmental epilepsy. In addition to being active in professional society and hospital committees, he has served on the editorial boards of 10 epilepsy and neurology journals and has been on multiple NIH study sections. Dr. Holmes has also reviewed grants from around the world including Canada, Israel, Australia, France, the UK and Belgium. He is the past president of the American Epilepsy Society and has received many honors including the American Epilepsy Society Research Award, Basic Science Award (1989), Pierre Gloor Research Award, American Clinical Neurophysiology Society (2001)