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To recognise infection, the immune system utilizes sensors on immune cells called “pattern recognition receptors” which detect invading pathogens. These sensors then trigger a number of responses which are aimed at providing protection against the infection.
Our group is focussed on understanding a particular group of these pathogen sensors, called the C-type lectins (CLRs), which stemmed from our discovery of the first receptor in this class, Dectin-1.
We have shown that CLRs are able to induce essential immune responses, and have determined the mechanisms that they utilize to trigger these effects. Importantly, we have shown that CLRs play a central role in protective immune responses during fungal infections and identified genetic variants of Dectin-1 in humans, which can confer susceptibility to disease.
We have also determined that defects in recognition by pathogen sensors can result in an untreatable fungal infection of the skin, called chromoblastomycosis; work which has led directly to the testing of a novel treatment in humans.
Our current research is aimed at gaining a more detailed understanding the role of CLRs in immunity during fungal infection, and exploring the roles and functions of new CLRs that we have recently identified.
To recognise infection, the immune system utilizes sensors on immune cells called “pattern recognition receptors” which detect invading pathogens. These sensors then trigger a number of responses which are aimed at providing protection against the infection.
Our group is focussed on understanding a particular group of these pathogen sensors, called the C-type lectins (CLRs), which stemmed from our discovery of the first receptor in this class, Dectin-1.
We have shown that CLRs are able to induce essential immune responses, and have determined the mechanisms that they utilize to trigger these effects. Importantly, we have shown that CLRs play a central role in protective immune responses during fungal infections and identified genetic variants of Dectin-1 in humans, which can confer susceptibility to disease.
We have also determined that defects in recognition by pathogen sensors can result in an untreatable fungal infection of the skin, called chromoblastomycosis; work which has led directly to the testing of a novel treatment in humans.
Our current research is aimed at gaining a more detailed understanding the role of CLRs in immunity during fungal infection, and exploring the roles and functions of new CLRs that we have recently identified.
研究兴趣
论文共 599 篇作者统计合作学者相似作者
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Vanessa I. Francis,Corin Liddle,Emma Camacho,Madhura Kulkarni, R. S. Samuel Jr, Jamie A. Harvey,Elizabeth R. Ballou,Darren D. Thomson,Gordon D. Brown,J. Marie Hardwick,Arturo Casadevall,Jonathan Witton,Carolina Coelho
Gabriela M. Avelar,Arnab Pradhan,Qinxi Ma,Emer Hickey,Ian Leaves,Corin Liddle, Alejandra V. Rodriguez Rondon,Ann-Kristin Kaune,Sophie Shaw,Corinne Maufrais,Natacha Sertour,Judith M. Bain,Daniel E. Larcombe,Leandro J. de Assis,Mihai G. Netea,Carol A. Munro,Delma S. Childers,Lars P. Erwig,Gordon D. Brown,Neil A. R. Gow,Marie-Elisabeth Bougnoux,Christophe d'Enfert,Alistair J. P. Brown, J. Andrew Alspaugh
MBio (2024)
The Cell Surfacepp.100128, (2024)
Mariano Malamud, Lauren Whitehead, Alasdair Mcintosh, Fabio Colella, Anke J. Roelofs,Takato Kusakabe,Ivy M. Dambuza, Annie Phillips-Brookes,Fabian Salazar, Federico Perez, Romey Shoesmith, Przemyslaw Zakrzewski, Emily A. Sey, Cecilia Rodrigues, Petruta L. Morvay,Pierre Redelinghuys,Tina Bedekovic,Maria J. G. Fernandes,Ruqayyah Almizraq,Donald R. Branch,Borko Amulic, Jamie Harvey, Diane Stewart,Raif Yuecel,Delyth M. Reid, Alex Mcconnachie, Matthew C. Pickering,Marina Botto,Iliyan D. Iliev,Iain B. McInnes,Cosimo De Bari,Janet A. Willment,Gordon D. Brown
NATURE (2024)
EL Houlder,S Gago,G Vere,D Conn,S Khan,D Thomson, MW Shepherd,R Lebedinec,GD Brown,M Bromley,AS MacDonald,PC Cook
biorxiv(2024)
Jennifer L Reedy, Kirstine Nolling Jensen,Arianne J Crossen,Kyle J Basham,Rebecca A Ward,Christopher M Reardon,Hannah Brown Harding, Olivia W Hepworth, Patricia Simaku, Geneva N Kwaku,Kazuya Tone,Janet A Willment,Delyth M Reid,Mark H T Stappers,Gordon D Brown,Jayaraj Rajagopal,Jatin M Vyas
Nature Communicationsno. 1 (2024): 1-16
Cellno. 19 (2024): 5121-5127
Gordon D Brown,Elizabeth R Ballou,Steven Bates,Elaine M Bignell,Andrew M Borman,Alexandra C Brand,Alistair J P Brown,Carolina Coelho,Peter C Cook,Rhys A Farrer,Nelesh P Govender,Neil A R Gow,William Hope,J Claire Hoving, Rachael Dangarembizi,Thomas S Harrison,Elizabeth M Johnson,Liliane Mukaremera, Mark Ramsdale,Christopher R Thornton,Jane Usher,Adilia Warris,Duncan Wilson
Nature reviews Microbiology (2024)
The European Physical Journal Dno. 7 (2024): 1-6
Gordon D. Brown,Elizabeth R. Ballou,Steven Bates,Elaine M. Bignell,Andrew M. Borman,Alexandra C. Brand,Alistair J. P. Brown,Carolina Coelho,Peter C. Cook,Rhys A. Farrer,Nelesh P. Govender,Neil A. R. Gow,William Hope,J. Claire Hoving,Rachael Dangarembizi,Thomas S. Harrison,Elizabeth M. Johnson,Liliane Mukaremera,Mark Ramsdale,Christopher R. Thornton,Jane Usher,Adilia Warris,Duncan Wilson
NATURE REVIEWS MICROBIOLOGYpp.1-18, (2024)
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作者统计
#Papers: 599
#Citation: 51391
H-Index: 111
G-Index: 218
Sociability: 8
Diversity: 0
Activity: 2
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