基本信息
浏览量:166
职业迁徙
个人简介
My work focuses on understanding how small molecules inside cells act as messengers to control physiology and how mimics of these messenger molecules can be used as chemical tools and drugs.
Recently, my group used repurposing to identify ebselen as a lithium mimetic and possible safer treatment for bipolar disorder. We took ebselen from molecule, through mouse to man. We have now licensed ebselen to a biotech who are taking it into phase 2 clinical trials for efficacy in treating bipolar disorder.
In the past, we developed chemical tools and methods related to calcium signalling that provided conclusive evidence that NAADP was a second messenger. Additionally, we used shape-based virtual screening to identify the NAADP antagonist Ned-19, which has greatly facilitated studies of NAADP in intact cells and whole animals.
Currently, we are identifying new chemical tools to help unravel the calcium signalling mechanisms and in so doing identify new drug targets. We are also interested in how NAADP is made and degraded as well as its perplexing desensitization and irreversible binding.
Recently, my group used repurposing to identify ebselen as a lithium mimetic and possible safer treatment for bipolar disorder. We took ebselen from molecule, through mouse to man. We have now licensed ebselen to a biotech who are taking it into phase 2 clinical trials for efficacy in treating bipolar disorder.
In the past, we developed chemical tools and methods related to calcium signalling that provided conclusive evidence that NAADP was a second messenger. Additionally, we used shape-based virtual screening to identify the NAADP antagonist Ned-19, which has greatly facilitated studies of NAADP in intact cells and whole animals.
Currently, we are identifying new chemical tools to help unravel the calcium signalling mechanisms and in so doing identify new drug targets. We are also interested in how NAADP is made and degraded as well as its perplexing desensitization and irreversible binding.
研究兴趣
论文共 177 篇作者统计合作学者相似作者
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Michael Strupp,Grant C. Churchill,Ivonne Naumann,Ulrich Mansmann,Amani Al Tawil, Anastasia Golentsova,Nicolina Goldschagg
Frontiers in neurology (2023)
T. Fields, T. M. Bremova, I Billington,G. C. Churchill,W. Evans, C. Fields,A. Galione,R. Kay, T. Mathieson,K. Martakis,M. Patterson,F. Platt,M. Factor,M. Strupp
TRIALSno. 1 (2023)
Journal of King Saud University Science/Maǧallaẗ ǧāmiʹaẗ al-malik Saʹūd al-ʹUlūmno. 7 (2023): 102817-102817
Areej Abuhammad,Nicola Laurieri, Alistair Rice,Edward D. Lowe,Nisha Singh, Saleem M. Naser, Samer S. Ratrout,Grant C. Churchill
Journal of biomolecular structure and dynamics/Journal of biomolecular structure & dynamicsno. 23 (2023): 14036-14048
crossref(2022)
Tom M. Quinn,Erin E. Gaughan,Annya Bruce,Jean Antonelli,Richard O'Connor,Feng Li,Sarah McNamara,Oliver Koch,Claire MacKintosh,David Dockrell,Timothy Walsh,Kevin G. Blyth,Colin Church,Juergen Schwarze,Cecilia Boz,Asta Valanciute,Matthew Burgess,Philip Emanuel,Bethany Mills,Giulia Rinaldi,Gareth Hardisty,Ross Mills,Emily Gwyer Findlay,Sunny Jabbal,Andrew Duncan, Sinead Plant,Adam D. L. Marshall,Irene Young,Kay Russell,Emma Scholefield,Alastair F. Nimmo, Islom B. Nazarov,Grant C. Churchill,James S. O. McCullagh,Kourosh H. Ebrahimi, Colin Ferrett,Kate Templeton,Steve Rannard,Andrew Owen,Anne Moore,Keith Finlayson,Manu Shankar-Hari,John Norrie, Richard A. Parker,Ahsan R. Akram,Daniel C. Anthony,James W. Dear,Nik Hirani,Kevin Dhaliwal
Aarti Jagannath,Norbert Varga,Robert Dallmann,Gianpaolo Rando,Pauline Gosselin,Farid Ebrahimjee,Lewis Taylor,Dragos Mosneagu,Jakub Stefaniak,Steven Walsh,Teele Palumaa,Simona Di Pretoro,Harshmeena Sanghani,Zeinab Wakaf,Grant C Churchill,Antony Galione,Stuart N Peirson,Detlev Boison,Steven A Brown,Russell G Foster,Sridhar R Vasudevan
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作者统计
#Papers: 177
#Citation: 8782
H-Index: 49
G-Index: 89
Sociability: 6
Diversity: 4
Activity: 27
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