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We study the molecular basis for major diseases of the aging eye, particularly cataract and age-related macular degeneration (AMD), using protein structural and functional genomics approaches.
Cataract: The major proteins that confer transparency and focusing power on the eye lens are the crystallins. These proteins are highly adapted for their roles and have fascinating and informative evolutionary histories. They are very stable, lasting for years without turnover while maintaining the necessary organization to keep the lens working as a lens. However, genetic variants or age-related changes can disrupt this organization, causing the proteins to change conformation and aggregate into particles, including amyloid-like fibrils, that can scatter light and make the lens opaque, forming a cataract. We are currently using x-ray crystallography and various spectroscopic techniques to study how the proteins interact normally in the lens and what happens as they aggregate. In particular, we have derived a remarkable high resolution structural model for a crystallin aggregation intermediate. We are also studying a potentially important interaction of γ-crystallins and actin, a major structural and functional component of all cells.
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论文共 144 篇作者统计合作学者相似作者
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Katherine M Peterson, Sanghamitra Mishra, Esther Asaki,John I Powell, Yiwen He,Alan E Berger,Dinusha Rajapakse,Graeme Wistow
PloS oneno. 9 (2024): e0293383-e0293383
Journal of the American Chemical Societyno. 32 (2023): 18063-18074
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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#Papers: 140
#Citation: 8278
H-Index: 46
G-Index: 87
Sociability: 6
Diversity: 3
Activity: 12
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