Guyatt has published over 1200 peer-reviewed articles in scientific journals, many in leading medical journals such as The New England Journal of Medicine, The Lancet, Journal of the American Medical Association, and The BMJ. According to the Web of Science, his work has been cited over 100,000 times; according to Google Scholar over 340,000 times. In a Google scholar tabulation of the world's most cited scientists, he is listed 14th.