Gideon Grogan works on the identification, characterisation and application of new enzymes that have potential applications in biotechnology, including those for the production of chiral pharmaceutical precursors and the bioprocessing of renewable materials. Recent work has focused on:

Oxygenases, including P450s, flavoprotein monooxygenases and peroxygenases
Reductases, including those that act on prochiral ketones (KREDs) and imines (IREDs) and enzymes that catalyse reductive amination reactions (RedAms)
Lyases that catalyse the asymmetric hydration of alkenes.
Ligases for the formation of amide bonds.
In each case, a multidisciplinary approach is adopted, involving synthetic chemistry, microbiology, molecular biology, and X-ray crystallography, with a view to engineering enzymes using in vitro evolution techniques for altered or improved characteristics.