Dr. Alexopoulos research focuses on: 1) Neurobiological disturbances in late- and mid-life mood disorders; 2) Novel treatment development; and 3) Improvement of community care. With neuropsychological and neuroimaging studies, he identified distinct syndromes of late-life depression (e.g. depression-executive dysfunction syndrome of late life, vascular depression) and described their biosignatures. He has been one of the first to use neurobiological models to streamline and simplify behavioral interventions so that they can be used broadly by community therapists. Dr. Alexopoulos’ work has been supported by numerous NIMH grants for treatments of patients with unmet needs including low income depressed, disabled, home-bound patients, depressed stroke victims, depressed patients with chronic obstructive pulmonary disease, and depressed patients with comorbid executive dysfunction.