Dr. Manley's research interests range from molecular aspects of traumatic brain injury (TBI) to the clinical care of TBI victims. This work spans from the laboratory to the bedside in an effort to develop translational models and data repositories to improve the diagnosis, prognosis and treatment of mild to severe brain injuries. He is the Contact Principal Investigator for both the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) U01 research project funded by the National Institute of Neurological Disorders and Strokee and the Department of Defense TBI Endpoints Development (TED) Initiative. Dr. Manley is also the contact PI of the recently awarded TRACK-TBI Network that will soon be launching innovative phase 2 clinical TBI trials.