Gaelle Friocourt

We work on cortical development with a focus on ARX, a gene involved in the development of GABAergic neurons. Using mouse models and iPS technology, we study the role of this gene in cognitive and fine motor functions such as language and prehension. In another project, we are investigating the effect of cystathionine-beta synthase (CBS) overexpression in brain function. The gene dosage of this enzyme appears critical in homocystinuria and Down syndrome.