The main research interests of Giampaolo Merlini is the investigation of physiopathology, epidemiology, clinical and therapeutic aspects of systemic amyloidoses.
He was then nominated director of the Biotechnology Research Laboratories of the IRCCS PSM in 1995 and promoted the acquisition of state-of-the art equipment for protein biochemistry, proteomics and genomics investigations. He founded the Italian Society of Amyloidosis in 1994 and established a network of clinical centers with expertise in systemic amyloidosis throughout Italy.