This is a broad remit because he believes it is essential to characterise physiological resolving inflammation, in order to understand chronic inflammatory disease. To facilitate studies in this area he utilises sophisticated in vitro models of vascular inflammation, including unique co-culture platforms using human cells. In addition his group have developed pre-clinical models of inflammation and inflammatory disease in which to conduct translational work. His group work under 3 major themes:

The cellular pathology of Athersclerosis: This theme has drawn long term support from the BHF, including 10 years of Personal Fellowship and 5 years of Programme Grant funding. Our recent work investigates the role of platelets in monocyte recruitment during atherogenesis.
Regulation of the inflammatory response by dietary omega-3 polyunsaturated fatty acids (n-3-PUFAs; AKA fish oils): The affects of n-3 PUFAs on endothelial cell and leukocyte biology is my niche area in this field, and we are using our in vitro modelling skills, to identify new steps in the regulation of leukocyte recruitment, differentiation and function.
Regulation of the inflammatory response by a novel peptide derived from the 14.3.3.zeta protein: We have identified an endogenous peptide mediated mechanism by which T cell recruitment is regulated. We believe that this unique pathway may be important in many auto-immune and/or chronic inflammatory diseases in which T cells contribute to the cellular pathology. A University of Birmingham spinout company, Viatem Ltd, is currently translating patents around this area into new anti-inflammatory drugs.