基本信息
浏览量:72
职业迁徙
个人简介
In addition to his role in the UACC, he is also a member of the NIEHS-funded Southwest Environmental Health Sciences Center, where he is a member of the Internal Advisory Board. He is the scientific director of the Genomics Shared Service, which derives its support from NIH, NIEHS, and the BIO5 Institute at the UA. Dr. Futscher's longstanding research interest is in the area of cancer epigenetics, with specific interests in the mechanisms of epigenetic dysfunction and the identification and development of epigenetic biomarkers for disease prognostication and epigenetic targets for therapeutic intervention. Dr. Futscher has longstanding collaborative research with UACC members Dr. Anne Cress (adaptive metastasis), Dr. Jay Gandolfi (arsenical-mediated carcinogenesis), and Dr. Jesse Martinez (p53's role in epigenetic dysfunction) among others.
Understanding epigenetic dysfunction in human cancer has been Dr. Futscher's primary research focus since establishing his own independent laboratory. This epigenetic research has moved into the area of noncoding RNAs and their potential role in cancer cell immortality. His research interest is in the molecular underpinnings of cancer cell immortality is a natural outgrowth of the productive collaborative research between his laboratory and Dr. Martha Stampfer’s laboratory (a co-Investigator on this project), and our 7 collaborative research papers listed below bear testimony to this fact.
Using Dr. Stampfer’s novel, reproducible method of inducing immortality in human mammary epithelial cells, the Futscher lab has identified a specific lncRNA and broader gene ontology that are expressed in normal, finite lifespan cells, but are consistently lost when these cells acquire immortality. We propose 2 specific aims to delineate the role of the specific lncRNA in cell immortality. Taken together, the scientific and technical expertise needed to successfully complete the proposed study on epithelial cell immortalization is in place. We predict that results from these studies will discover new targets and pathways that lead to epithelial cell immortalization - a fundamental aspect of carcinoma development.
Dr. Futscher has provided scientific oversight of the Cancer Center’s Genomics Shared Resource since its inception, and is currently Co-Director of the Resource.
The Futscher lab’s primary research focus is cancer epigenetics. We use comprehensive genomic approaches to investigate the epigenomic dysfunction that drives human cancer. The use of genome-wide approaches guarantees the capture of all of the information regarding epigenetic change in human cancer.
From this comprehensive data of the normal and diseased human epigenomes, we employ advanced in silico and molecular biological approaches to generate new knowledge and discover the decisive epigenetic events that drive human carcinogenesis. The long-term objective of these studies is the development of epigenetic markers for toxicant exposure, disease detection and prognostication, and the identification of novel targets for molecularly directed cancer therapy.
Understanding epigenetic dysfunction in human cancer has been Dr. Futscher's primary research focus since establishing his own independent laboratory. This epigenetic research has moved into the area of noncoding RNAs and their potential role in cancer cell immortality. His research interest is in the molecular underpinnings of cancer cell immortality is a natural outgrowth of the productive collaborative research between his laboratory and Dr. Martha Stampfer’s laboratory (a co-Investigator on this project), and our 7 collaborative research papers listed below bear testimony to this fact.
Using Dr. Stampfer’s novel, reproducible method of inducing immortality in human mammary epithelial cells, the Futscher lab has identified a specific lncRNA and broader gene ontology that are expressed in normal, finite lifespan cells, but are consistently lost when these cells acquire immortality. We propose 2 specific aims to delineate the role of the specific lncRNA in cell immortality. Taken together, the scientific and technical expertise needed to successfully complete the proposed study on epithelial cell immortalization is in place. We predict that results from these studies will discover new targets and pathways that lead to epithelial cell immortalization - a fundamental aspect of carcinoma development.
Dr. Futscher has provided scientific oversight of the Cancer Center’s Genomics Shared Resource since its inception, and is currently Co-Director of the Resource.
The Futscher lab’s primary research focus is cancer epigenetics. We use comprehensive genomic approaches to investigate the epigenomic dysfunction that drives human cancer. The use of genome-wide approaches guarantees the capture of all of the information regarding epigenetic change in human cancer.
From this comprehensive data of the normal and diseased human epigenomes, we employ advanced in silico and molecular biological approaches to generate new knowledge and discover the decisive epigenetic events that drive human carcinogenesis. The long-term objective of these studies is the development of epigenetic markers for toxicant exposure, disease detection and prognostication, and the identification of novel targets for molecularly directed cancer therapy.
研究兴趣
论文共 199 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Billie Bixby, Lukas Vrba, Jyoti Lenka,Marc M. Oshiro,George S. Watts, Trina. Hughes,Heidi Erickson,Madhav Chopra, James L. Knepler,Kenneth S. Knox, Lisa Jarnagin, Raed Alalawi, Mrinalini Kala, Richard Bernert, Joshua Routh,Denise J. Roe,Linda L. Garland,Bernard W. Futscher, Mark A. Nelson
SCIENTIFIC REPORTSno. 1 (2024)
Billie Bixby,Lukas Vrba, Jyoti Lenka,Marc M. Oshiro,George S. Watts, Trina. Hughes,Heidi Erickson,Madhav Chopra,James L. Knepler,Kenneth S. Knox, Lisa Jarnagin,Raed Alalawi,Mrinalini Kala, Richard Bernert, Joshua Routh,Denise J. Roe,Linda L. Garland,Bernard W. Futscher,Mark A. Nelson
Scientific Reportsno. 1 (2024): 1-8
Marc M. Oshiro, Ryan K. Akhbari,George S. Watts,Bernard W. Futscher,Lukas Vrba, Richard A. Bernert,Mark A. Nelson, Geoffrey D. Block
Gastroenterologyno. 6 (2023): S-1313-S-1314
加载更多
作者统计
#Papers: 198
#Citation: 13162
H-Index: 55
G-Index: 114
Sociability: 7
Diversity: 0
Activity: 1
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn