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职业迁徙
个人简介
Our group has already identified the factor Noggin, which efficiently induces differentiation of myocardial progenitors from ES cells. In addition, we have identified a factor that induces cardiomyocyte differentiation from myocardial progenitors and a factor that causes immature cardiomyocytes that have just differentiated to undergo cell division. Moreover, by identifying a dye that is capable of specifically staining cardiomyocytes and developing a technique to separate the cardiomyocytes it has become possible to efficiently transplant cardiomyocytes without forming teratomas. In this project we plan to conduct basic research and a preclinical study in order to realize "a regenerated cardiomyocyte transplantation method using human ES cells" as an alternative to replace heart transplantation as a means of treating severe heart failure in humans. More specifically, we aim to (1) establish a technique to use human ES cells to produce large numbers of cardiomyocytes, (2) separate and purify regenerated cardiomyocytes and undifferentiated stem cells/non-cardiomyocytes and establish a transplantation technique that is not associated with teratoma formation, (3) transplant human regenerated cardiomyocytes into monkey hearts free of heart disease and assess pathological changes immediately after transplantation, whether teratomas have formed, arrhythmogenicity, etc., and (4) transplant human regenerated cardiomyocytes into the hearts of monkeys with heart failure after producing a myocardial infarction, and to encompass all preclinical studies prior to clinical application.
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论文共 1322 篇作者统计合作学者相似作者
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JACC: Asiano. 4 (2024): 306-319
Akira Kunitomi,Ryoko Hirohata,Mitsujiro Osawa, Kaho Washizu, Vanessa Arreola,Norikazu Saiki,Tomoaki M. Kato,Masaki Nomura, Haruko Kunitomi,Tokiko Ohkame, Yusuke Ohkame,Jitsutaro Kawaguchi,Hiroto Hara,Kohji Kusano,Takuya Yamamoto,Yasuhiro Takashima,Shugo Tohyama,Shinsuke Yuasa,Keiichi Fukuda,Naoko Takasu,Shinya Yamanaka
STEM CELL REPORTSno. 5 (2024): 710-728
Wenqi Ma,Kangni Jia, Haomai Cheng, Hong Xu, Zhigang Li,Hang Zhang,Hongyang Xie, Hang Sun,Lei Yi,Zhiyong Chen,Shengzhong Duan,Motoaki Sano,Keiichi Fukuda,Lin Lu,Fei Gao,Ruiyan Zhang,Xiaoxiang Yan
Circulation research (2024)
Hideki Kobayashi,Shugo Tohyama,Noburo Ohashi,Hajime Ichimura,Shuji Chino,Yusuke Soma,Hidenori Tani,Yuki Tanaka, Xiao Yang,Naoko Shiba,Shin Kadota, Kotaro Haga,Taijun Moriwaki,Yuika Morita-Umei,Tomohiko C. Umei,Otoya Sekine,Yoshikazu Kishino,Hideaki Kanazawa,Hiroyuki Kawagishi,Mitsuhiko Yamada, Kazumasa Narita,Takafumi Naito,Tatsuichiro Seto,Koichiro Kuwahara,Yuji Shiba,Keiichi Fukuda
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2024): 90-100
Toshiki Kuno, Yoshihisa Miyamoto,Keitaro Akita,Satoshi Shoji,Yohei Numasawa,Ikuko Ueda,Shigetaka Noma,Keiichi Fukuda,Shun Kohsaka
Circulation journal : official journal of the Japanese Circulation Society (2024)
Tetsuya Saito,Taku Inohara,Hikaru Tsuruta,Fumiaki Yashima,Hideyuki Shimizu,Keiichi Fukuda,Yohei Ohno,Hidetaka Nishina,Masaki Izumo,Masahiko Asami,Toru Naganuma,Kazuki Mizutani,Masahiro Yamawaki, Norio Tada,Futoshi Yamanaka,Shinichi Shirai,Masahiko Noguchi,Hiroshi Ueno,Kensuke Takagi,Yusuke Watanabe,Masanori Yamamoto,Kentaro Hayashida
JACC Asiano. 4 (2024): 306-319
Kangni Jia, Haomai Cheng, Wenqi Ma,Lingfang Zhuang,Hao Li, Zhigang Li, Ziyang Wang, Hang Sun,Yuke Cui,Hang Zhang,Hongyang Xie, Lei Yi,Zhiyong Chen, Motoaki Sano,Keiichi Fukuda,Lin Lu, Jun Pu,Yan Zhang,Ling Gao,Ruiyan Zhang,Xiaoxiang Yan
Circulationno. 14 (2024): 1121-1139
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#Papers: 1318
#Citation: 30647
H-Index: 78
G-Index: 131
Sociability: 8
Diversity: 1
Activity: 10
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