Research interests include: development of accurate prognostic and diagnostic models, model validation, clinical trials, observational clinical research, cardiovascular research, technology evaluation, pharmaceutical safety, Bayesian methods, quantifying predictive accuracy, missing data imputation, statistical graphics and reporting
Honors and service include: founding department chair, 2003–2017; fellow, American Statistical Association (ASA; elected 2005); associate editor, Statistics in Medicine; W. J. Dixon for Excellence in Statistical Computing (ASA, 2014); senior biostatistics advisor, Office of the Center Director, FDA Center for Drug Evaluation and Research (CDER, 2022–present); expert statistical advisor, Office of Biostatistics, CDER (2016–2020); scientific advisory board member, Science Translational Medicine; policy advisory board member, Journal of Clinical Epidemiology