Rationale: CRS-HIPEC is a treatment option for peritoneal surface malignancies. Nutritional care is believed to be an important factor in postoperative outcome. Our aim was to analyze changes in nutrition-related parameters, including handgrip strength (HGS), after this procedure. Methods: Retrospective study of 30 patients undergoing CRS-HIPEC at our institution. Clinical, biochemical and anthropometric data were collected baseline,1 week and 2 months after surgery. HGS was measured using Jamar dynamometer 1 week and 2 months after surgery. Statistical significance p<0,05. Results: 6/24 (male/female) patients were included. 16 ovarian cancer, 9 colorectal, 5 pseudomyxoma peritonei. Baseline characteristics: age 58,8±10,9 years; BMI 24,1±4,6 kg/m2, albumin 4,1±0,3 g/l, prealbumin 25±6,4 mg/dl. Subjective global assessment (SGA): A 65,5% B 34,5%; 1 week after surgery: HGS 23,4± 22 percentile (29,2% women<16 kg, 50% men<27 kg). Albumin 2,9±0,4 g/l and prealbumin 20,5±7,5 mg/dl significantly decreased from baseline (p< 0,009). Length of hospital stay (LOS) 16,8 days (9-39) increased in patients with BMI<20 (23,4 days) and SGA B (20,2 days) (p< 0,05). Changes 2 months after surgery: BMI 21,4±2,9 kg/m2, HGS 32,3 ±29 percentile (8,3% women <16 kg, 33,3% men <27 kg); albumin 3,8±0,4 g/l, prealbumin 26,1±0,4 mg/dl (p<0,05). In those patients who needed reoperation (31%) or experienced infectious complications (27,6%), there was a significantly lower recovery after 2 months in HGS percentile (p< 0,02), weight, BMI and albumin levels (p< 0,05). Conclusion: Our results show that low HGS is a common finding after CRS-HIPEC with a favorable evolution after 2 months. Nutritional and HGS recovery is affected if reoperation or infectious complications occur. LOS is higher in patients with a worse nutritional status before CRS-HIPEC (low BMI and SGA B) Disclosure of Interest: None declared