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个人简介
Ivan Zanoni laboratory studies innate immune cell biology as a means of understanding the earliest events that initiate immunity to infection or drive the development of immune-mediated diseases. He focused primarily on the study of Pattern Recognition Receptor (PRR) signaling pathways. PRRs initiate all immune responses and activate a network of transcription factors that orchestrate the inflammatory response. The organizing principles that govern PRR signaling are largely unknown and their elucidation will likely answer several fundamental questions about the pathophysiological development of the inflammatory process. His work established the first example of a cellular response to bacterial lipopolysaccharide (LPS) that does not depend on Toll-like Receptor (TLR)4, the prototype of the TLRs that are the best characterized family of PRRs. It has long been dogma that signaling via TLR4 is the only means by which mammalian cells respond to LPS. Ivan Zanoni uncovered that CD14 controls the LPS-induced endocytosis of TLR4, a process that is critical for the signaling functions of this receptor in numerous mammalian cell types. He also found that dendritic cells respond to LPS in a TLR4-independent manner that is important for regulating the activation of the Nuclear Factor of Activated T cells (NFAT). This work blurred the line between innate and adaptive immunity, and documented that NFAT operates in cells of both types of immunity. His findings that TLR4-independent LPS response pathway exists and that CD14 has autonomous signaling capacity open new perspectives on the study of LPS-driven inflammatory diseases and, in general, on the potential of co-receptors to modify and integrate the immune responses elicited by their cognate receptor. Goals of Dr. Zanoni’s research include: Understanding the molecular mechanisms that govern the cross-talk between co-receptors and their cognate receptors; Understanding how NFAT activation in innate immune cells regulates the inflammatory process; Understanding how PRRs signaling contributes to the development of inflammatory diseases and metabolic disorders.
研究兴趣
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Journal of medical virologyno. 8 (2024): e29868-e29868
Kautilya K Jena, Julien Mambu, Daniel Boehmer,Benedetta Sposito, Virginie Millet, Joshua de Sousa Casal, Hayley I Muendlein, Roberto Spreafico, Romain Fenouil, Lionel Spinelli, Sarah Wurbel, Chloé Riquier, Franck Galland, Philippe Naquet, Lionel Chasson, Megan Elkins, Vanessa Mitsialis, Natália Ketelut-Carneiro, Katlynn Bugda Gwilt, Jay R Thiagarajah,Hai-Bin Ruan,Zhaoyu Lin,Egil Lien,Feng Shao, Janet Chou,Alexander Poltorak, Jose Ordovas-Montanes, Katherine A Fitzgerald,Scott B Snapper, Achille Broggi,Ivan Zanoni
Cell (2024)
Trends in immunologyno. 11 (2024): 871-891
Current Opinion in Immunology (2024): 102423-102423
Cancer Immunology Researchpp.OF1-OF9, (2024)
The Journal of Immunologyno. 1_Supplement (2024): 0836_7939-0836_7939
IJID Regions (2024): 100411-100411
Dania Zhivaki,Stephanie N. Kennedy, Josh Park,Francesco Boriello,Pascal Devant,Anh Cao,Kristin M. Bahleda, Shane Murphy,Cristin McCabe,Charles L. Evavold, Kate L. Chapman,Ivan Zanoni,Orr Ashenberg,Ramnik J. Xavier,Jonathan C. Kagan
Cell (2024)
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#Papers: 241
#Citation: 11903
H-Index: 52
G-Index: 107
Sociability: 7
Diversity: 3
Activity: 307
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