Our research sits firmly at the boundary of basic and translational sciences where scientific advances in for example, understanding the genetic and biochemical mechanisms of drug resistance have been developed into practical diagnostic tests, evaluated in multicenter trials and implemented into NHS and clinical practice. These have involved utlising multiple approaches including social and behavioural to address clinical problems and achieve desired goals. Similarly the patients we typically deal with (eg TB, HIV, multi-cultural, ethnic and linguistic, frequently with major social problems including alcoholism, intra-venous drug abuse, homeless ness, prior imprisonment) require a multi-disciplinary scientific and clinical approach to address complex needs and perceptions about their illness. Addressing their major clinical needs often involves solving medically minor but patient-important issues relating to benefits, eye and foot care for example.