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The overarching goal of the Erwin lab is to reveal molecular mechanisms of gene by environment interactions that alter neural development and liability for human brain disorders. Towards this goal, we study the contribution of retroelements and somatic mosaicism to human brain function by integrating human stem cell models, postmortem tissue and computational approaches. Retroelements are endogenous components of eukaryotic genomes that are able to amplify to new locations in the genome through an RNA intermediate. Retroelements comprise nearly half of the human genome, and specific subsets are primate and even human specific. Our previous work demonstrated that an endogenous retroelement, named LINE-1, causes genetic differences between neurons within the same neurotypic brain, termed somatic mosaicism. Current work focuses on the mechanisms and consequences of retroelement activity and somatic mosaicism in schizophrenia, aging, and a rare neurodegenerative movement disorder X-linked Dystonia Parkinsonism, which is caused by an inherited SVA retroelement. By elucidating these poorly understood mechanism, we aim to identify novel targets for neuroprotective intervention.
研究兴趣
论文共 41 篇作者统计合作学者相似作者
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medRxiv : the preprint server for health sciences (2024)
Nature communicationsno. 1 (2024)
Ethan Tietze,Andre Rocha Barbosa,Bruno Araujo,Veronica Euclydes, Bailey Spiegelberg,Hyeon Jin Cho, Yong Kyu Lee, Yanhong Wang, Alejandra McCord, Alan Lorenzetti,Arthur Feltrin,Joyce van de Leemput,Pasquale Di Carlo,Gianluca Ursini,Kynon J. Benjamin,Helena Brentani,Joel E. Kleinman,Thomas M. Hyde,Daniel R. Weinberger,Ronald McKay,Joo Heon Shin,Tomoyo Sawada,Apua C. M. Paquola,Jennifer A. Erwin
Ethan Tietze,Andre Rocha Barbosa, Bruno Henrique Silva Araujo,Veronica Euclydes,Hyeon Jin Cho, Yong Kyu Lee,Arthur Feltrin, Bailey Spiegelberg, Alan Lorenzetti,Joyce van de Leemput,Pasquale Di Carlo,Tomoyo Sawada,Gianluca Ursini,Kynon J. Benjamin,Helena Brentani,Joel E. Kleinman,Thomas M. Hyde,Daniel R. Weinberger,Ronald McKay,Joo Heon Shin,Apua C.M. Paquola,Jennifer A. Erwin
biorxiv(2023)
medRxiv (Cold Spring Harbor Laboratory) (2022)
Kynon J. M. Benjamin, Qiang Chen,Andrew E. Jaffe,Joshua M. Stolz,Leonardo Collado-Torres,Louise A. Huuki-Myers,Emily E. Burke,Ria Arora,Arthur S. Feltrin,André Rocha Barbosa,Eugenia Radulescu,Giulio Pergola,Joo Heon Shin,William S. Ulrich,Amy Deep-Soboslay,Ran Tao,Mitsuyuki Matsumoto,Thomas M. Hyde,Joel E. Kleinman,Jennifer A. Erwin,Daniel R. Weinberger,Apuã C. M. Paquola
bioRxiv (Cold Spring Harbor Laboratory) (2022)
Seminars in Cell & Developmental Biology (2021): 68-80
Shinichi Fukuda,Akhil Varshney,Benjamin J. Fowler,Shao-bin Wang,Siddharth Narendran,Kameshwari Ambati,Tetsuhiro Yasuma,Joseph Magagnoli,Hannah Leung,Shuichiro Hirahara,Yosuke Nagasaka,Reo Yasuma,Ivana Apicella,Felipe Pereira,Ryan D. Makin,Eamonn Magner,Xinan Liu,Jian Sun,Mo Wang,Kirstie Baker,Kenneth M. Marion,Xiwen Huang,Elmira Baghdasaryan,Meenakshi Ambati,Vidya L. Ambati,Akshat Pandey,Lekha Pandya,Tammy Cummings,Daipayan Banerjee,Peirong Huang,Praveen Yerramothu,Genrich Tolstonog,Ulrike Held,Jennifer A. Erwin,Apua C. M. Paquola,Joseph R. Herdy,Yuichiro Ogura,Hiroko Terasaki,Tetsuro Oshika,Shaban Darwish, Ramendra K. Singh,Saghar Mozaffari,Deepak Bhattarai,Kyung Bo Kim,James W. Hardin,Charles L. Bennett,David R. Hinton,Timothy E. Hanson,Christian Rover,Keykavous Parang,Nagaraj Kerur,Jinze Liu,Brian C. Werner,S. Scott Sutton,Srinivas R. Sadda,Gerald G. Schumann,Bradley D. Gelfand,Fred H. Gage,Jayakrishna Ambati
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 6 (2021): 30-35
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作者统计
#Papers: 41
#Citation: 4816
H-Index: 18
G-Index: 26
Sociability: 6
Diversity: 3
Activity: 11
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