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Bio
As a laboratory of developmental biology, our guiding interest is to comprehend how complex biological patterns can be assembled with stereotyped precision. This requires a detailed understanding of how cells come to execute appropriate behaviors — be it adoption of specific cell fates, proliferation, or apoptosis — and do so at the right times, in the right places, and in the right numbers. Dysfunction of processes that direct normal tissue patterning results not only in developmental disorder but also underlies adult disease. Tellingly, many factors whose mutation is relevant to human cancer were first identified and characterized with respect to development in model organisms. To study these topics, we utilize integrative approaches, combining genetics, biochemistry, and genomewide approaches, to elucidate detailed molecular mechanisms and use these to understand in vivo biology as well as decipher genomic regulatory networks.
Research Interests
Papers共 167 篇Author StatisticsCo-AuthorSimilar Experts
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bioRxiv : the preprint server for biology (2024)
NUCLEIC ACIDS RESEARCHno. 3 (2024): 1080-1089
bioRxiv : the preprint server for biology (2024)
ELIFE (2024)
Life science allianceno. 12 (2023): e202302000-e202302000
PLOS GENETICSno. 8 (2023): e1010914-e1010914
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 41 (2023): e2306727120-e2306727120
Genes & developmentno. 21-24 (2023): 1041-1051
PLoS geneticsno. 6 (2023): e1010787-e1010787
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