Most recently, in addition to continuing basic physiologic research of the lung, he has established a combination of single and multi-spectral multidetector row spiral CT imaging methodology to objectively follow human lung pathology and pathophysiology with a particular emphasis on inflammatory lung diseases. The centerpiece of APPIL is a Siemens SOMATOM Force CT scanner. Dr. Hoffman is the author of more than 570 journal articles and 21 book chapters in the field of dynamic volumetric imaging of the lung and heart and served for 5 years as the founding chair of the Physiology and Function from Multidimensional Imaging sessions of the SPIE Medical Imaging conference. Dr. Hoffman was inducted into the college of fellows of the American Institute for Medical and Biological Engineering in March of 2000 and was elected into the Fleischner Society in May 2005 and named a Distinguished Investigator by The Academy for Radiology and Biomedical Imaging Research in 2018. He received the 2013 John West award for Outstanding Contributions to the Field of Functional Pulmonary Imaging from the IWPFI, the 2014 Joseph R Rodarte Award for Scientific Distinction from the Respiratory Structure and Function Assembly of the American Thoracic Society and the 2018 Alton Ochsner Award "relating smoking and disease." He is a fellow of the European Respiratory Society and the American Thoracic Society. Dr. Hoffman's laboratory is dedicated to the use of advanced imaging methodologies for the exploration of normal and pathologic physiology of the lung with specific areas of interest relating to inflammatory lung diseases including COPD, asthma and environmentally induced pathologies. APPIL serves as the Radiology Center for numerous large multi-center studies utilizing imaging to phenotype the lung as a component of the study (including SPIROMICS, MESA Lung, SARP, PreCISE, British Lung Foundation Early COPD).