Enno Schefuß focuses on Oceanography, Holocene, Precipitation, Sea surface temperature and Monsoon. His studies in Oceanography integrate themes in fields like Sediment, Terrigenous sediment, Intertropical Convergence Zone and Rhizophora. His biological study spans a wide range of topics, including Subtropics and Climate change.

His work focuses on many connections between Subtropics and other disciplines, such as Ocean current, that overlap with his field of interest in Paleoclimatology. His research integrates issues of Climatology and Tropics in his study of Holocene. Specifically, his work in Sea surface temperature is concerned with the study of TEX86.