She is author of over 800 peer-reviewed publications that focus on the genetics, epidemiology, and prognosis of a variety of cardiovascular conditions and markers including atrial fibrillation, vascular function, and systemic inflammation. She has been continuously NIH funded since 1998, and currently is multi-Principal Investigator on an R01 atrial fibrillation grant [2R01HL092577], several chronic pain grants, and is the Training Director on the Boston University American Heart Association Strategically Focused Research Network on Cardio-Oncology. She is an internationally recognized expert on the epidemiology of atrial fibrillation. Dr. Benjamin has Co-Chaired the NIH National Heart Lung and Blood Institutes’ (NHLBI) Atrial Fibrillation Working Group, which advised the NHLBI’s atrial fibrillation research agenda, and resulted in 6 publications.

Dr. Benjamin has conducted research at the Framingham Study since 1988. She is a Member of the Executive Committee, and is Co-Director of the Medical Endpoints Committee. She was Principal Investigator of the grant that recruited the second generation of the Framingham Study's ethnic/racial minority cohort, the Omni Study.

In addition to her research, she is the inaugural Associate Provost for Faculty Development for Boston University Medical Campus, and the inaugural Vice Chair for Faculty Development and Diversity, BU Department of Medicine. She co-designed and co-leads Faculty Development Programs for Early, Mid-Career, Under-Represented Ethnic and Racial, Women, and Clinical Leaders. In 2023 she completed the Columbia University Advanced Coaching Certification.

A passionate and dedicated mentor, she has won local and national awards for mentoring, education, and research. She was inducted into the Association of American Physicians and she won the 2020 Alliance for Academic Internal Medicine Diversity, Equity, and Inclusion Award.