Her research has also provided insight into the post-translational modifications that might regulate the mPTP. A number of studies focused on detailed mechanisms by which nitric oxide and its post-translational modification, S-nitrosylation (SNO), mediate protection. Several novel studies were published showing that SNO occupancy is sufficient to protect by shielding key cysteines from oxidation (Kohr et al Circ Res, 2012). Further studies demonstrated that SNO of cysteine 144 of tripartite motif-containing protein 72 (TRIM72) stabilized TRIM72 (Kohr et al J Mol Cell Cardiol, 2014). These studies demonstrate crosstalk between SNO and oxidation and show that competition between post translational modifications at key amino acids can act as a regulatory switch and regulate the response to cell death stimuli. Additional studies demonstrated that SNO of mitochondrial proteins is important in mediating cardioprotection by hydrogen sulfide (Sun et al Cardiovas. Res, 2016) and postconditioning (Tong et al Am. J. Physiol, 2013).