Eline Koers

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个人简介

I work on processes early in GPCR biogenesis (e.g. GPCR folding and membrane insertion) and the effect of disease-related mutations and protein homeostasis on the process.

研究兴趣

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A universal cannabinoid CB1 and CB2 receptor TR-FRET kinetic ligand binding assay

Leire Borrega-Roman,Bradley L. Hoare,Miroslav Kosar,Roman C. Sarott, Kacper J. Patej,Jara Bouma, Morgan Scott-Dennis,Eline J. Koers,Thais Gazzi, Leonard Mach,Sergio Barrondo,Joan Sallés,Wolfgang Guba,Eric Kusznir, Marc Nazaré,Arne C. Rufer,Uwe Grether,Laura H. Heitman, Erick M. Carreira,David A. Sykes,Dmitry B. Veprintsev

biorxiv（2024）

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Protein Tethering for Single-Molecule Force Spectroscopy

Mario J Avellaneda,Eline J Koers,Vanda Sunderlikova,Sander J Tans

Methods in molecular biology (Clifton, N.J.) (2024): 57-67

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Probing Single Chaperone Substrates

F. Wruck,M. J. Avellaneda, M. M. Naqvi,E. J. Koers,K. Till, L. Gross,F. Moayed, A. Roland,L. W. H. J. Heling,A. Mashaghi,S. J. Tans

New Developments in NMR (2024): 278-318

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Probing drug-target engagement of soluble Gαi1 protein using the SolThermoBRET thermal shift assay

Oscar Brod, Darya Plevako, Themiya Perera,Pattarin Hompluem,Eline J. Koers,Manuel Hilbert,David A. Sykes,Dmitry B. Veprintsev

biorxiv（2024）

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Molecular Recognition of an Odorant by the Murine Trace Amine-Associated Receptor TAAR7f

Anastasiia Gusach,Yang Lee, Armin Nikpour Khoshgrudi,Elizaveta Mukhaleva,Ning Ma,Eline J Koers, Qingchao Chen,Patricia C Edwards,Fanglu Huang,Jonathan Kim,Filippo Mancia,Dmitry B Verprintsev,Nagarajan Vaidehi,Simone N Weyand,Christopher G Tate

Nature Communicationsno. 1 (2024)

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ThermoBRET: a Ligand-Engagement Nanoscale Thermostability Assay Applied to GPCRs

Bradley L. Hoare, David N. Tippett, Amandeep Kaur,Sean A. Cullum,Tamara Miljus,Eline J. Koers,Clare R. Harwood,Nicola Dijon,Nicholas D. Holliday,David A. Sykes,Dmitry B. Veprintsev

CHEMBIOCHEMno. 2 (2024)

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Detection of cannabinoid receptor type 2 in native cells and zebrafish with a highly potent, cell-permeable fluorescent probe

Thais Gazzi,Benjamin Brennecke,Kenneth Atz,Claudia Korn,David Sykes,Gabriel Forn-Cuni,Patrick Pfaff,Roman C. Sarott,Matthias Westphal,Yelena Mostinski, Leonard Mach,Malgorzata Wasinska-Kalwa,Marie Weise,Bradley L. Hoare,Tamara Miljus, Maira Mexi,Nicolas Roth,Eline J. Koers,Wolfgang Guba,Andre Alker,Arne C. Rufer,Eric A. Kusznir,Sylwia Huber,Catarina Raposo,Elisabeth A. Zirwes,Anja Osterwald,Anto Pavlovic,Svenja Moes,Jennifer Beck,Matthias Nettekoven,Irene Benito-Cuesta,Teresa Grande,Faye Drawnel,Gabriella Widmer,Daniela Holzer,Tom van der Wel,Harpreet Mandhair,Michael Honer,Jurgen Fingerle,Joerg Scheffel,Johannes Broichhagen,Klaus Gawrisch,Julian Romero,Cecilia J. Hillard,Zoltan V. Varga,Mario van der Stelt,Pal Pacher,Jurg Gertsch,Christoph Ullmer,Peter J. McCormick,Sergio Oddi,Herman P. Spaink,Mauro Maccarrone,Dmitry B. Veprintsev,Erick M. Carreira,Uwe Grether,Marc Nazare

CHEMICAL SCIENCE（2022）

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Protein Chain Collapse Modulation and Folding Stimulation by GroEL-ES

Mohsin M. Naqvi,Mario J. Avellaneda,Andrew Roth,Eline J. Koers,Antoine Roland,Vanda Sunderlikova,Gunter Kramer,Hays S. Rye,Sander J. Tans

Science advances（2022）

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Combined Docking and Machine Learning Identify Key Molecular Determinants of Ligand Pharmacological Activity on Β2 Adrenoceptor

Mireia Jimenez-Roses,Bradley Angus Morgan,Maria Jimenez Sigstad,Thuy Duong Zoe Tran,Rohini Srivastava,Asuman Bunsuz,Leire Borrega-Roman,Pattarin Hompluem,Sean A. Cullum,Clare R. Harwood,Eline J. Koers,David A. Sykes,Iain B. Styles,Dmitry B. Veprintsev

Pharmacology research & perspectives（2022）

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Direct Observation of Hsp90-induced Compaction in a Protein Chain

Alireza Mashaghi,Fatemeh Moayed,Eline J. Koers, Yang Zheng,Katharina Till,Gunter Kramer,Matthias P. Mayer,Sander J. Tans

Cell Reports（2022）

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论文共 30 篇作者统计合作学者相似作者