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Receptor tyrosine kinases of the Eph family and their ligands, the ephrins, represent an important cell communication system that controls a vast array physiological and disease processes. For example, Eph receptors and ephrins take part in the formation of blood vessels, including the blood vessels that feed tumors, and regulate the malignant properties of cancer cells and their interplay with the tumor microenvironment. They also regulate the formation, plasticity and regeneration of neuronal circuits as well as neurodegenerative processes such as those occurring in amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease. The signal transduction mechanisms of Eph receptors are intriguing, and complex, because these receptors engage in multiple modes of signaling. Binding to ephrin ligands on the surface of neighboring cells induces canonical signaling involving receptor clustering, autophosphorylation on tyrosine residues, and kinase activity-dependent downstream signaling. Binding to the Eph receptors can also cause the ephrins, which have a cytoplasmic domain or a GPI-anchor, to transmit signals. This leads to bidirectional signals emanating from Eph receptor-ephrin complexes positioned at sites of cell-cell contact. In addition, at least some Eph receptors can also signal through non-canonical mechanisms that are independent of ligand binding and kinase activity, for example through interplay with other receptor tyrosine kinase families and with serine/threonine kinases.
Our research investigates Eph receptor signaling activities in order to understand their role in normal physiology and in pathological conditions such as cancer and neurodegenerative disorders. This knowledge is useful for the development of disease treatments based on modulating Eph receptor/ephrin activities. Ongoing efforts in our laboratory also focus on the development of agents targeting Eph receptors for research and translational applications.
Our research investigates Eph receptor signaling activities in order to understand their role in normal physiology and in pathological conditions such as cancer and neurodegenerative disorders. This knowledge is useful for the development of disease treatments based on modulating Eph receptor/ephrin activities. Ongoing efforts in our laboratory also focus on the development of agents targeting Eph receptors for research and translational applications.
研究兴趣
论文共 267 篇作者统计合作学者相似作者
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NATURE REVIEWS CANCERno. 1 (2024): 5-27
Journal of biological chemistry/The Journal of biological chemistrypp.107441-107441, (2024)
Khalid N M Abdelazeem,Diemmy Nguyen,Sophia Corbo, Laurel B Darragh,Mike W Matsumoto,Benjamin Van Court, Brooke Neupert,Justin Yu, Nicholas A Olimpo,Douglas Grant Osborne,Jacob Gadwa, Richard B Ross, Alexander Nguyen,Shilpa Bhatia,Mohit Kapoor, Rachel S Friedman, Jordan Jacobelli, Anthony J Saviola,Michael W Knitz,Elena B Pasquale,Sana D Karam
bioRxiv : the preprint server for biology (2024)
Joshua P. Sasine, Natalia Y. Kozlova, Lisa Valicente, Jennifer Dukov, Dana H. Tran,Heather A. Himburg, Sanjeev Kumar, Sarah Khorsandi, Aldi Chan, Samantha Grohe,Michelle Li,Jenny Kan,Mary E. Sehl,Gary J. Schiller,Bryanna Reinhardt,Brijesh Kumar Singh,Ritchie Ho,Peibin Yue,Elena B. Pasquale,John P. Chute
pubmed(2024)
Joshua P. Sasine, Natalia Y. Kozlova, Lisa Valicente, Jennifer Dukov, Dana H. Tran, Heather A. Himburg, Sanjeev Kumar, Sarah Khorsandi, Aldi Chan, Samantha Grohe,Michelle Li,Jenny Kan, Mary E. Sehl,Gary J. Schiller, Bryanna Reinhardt,Brijesh Kumar Singh, Ritchie Ho,Peibin Yue,Elena B. Pasquale, John P. Chute
crossref(2024)
crossref(2023)
Kim H.T. Paraiso,Meghna Das Thakur,Bin Fang,John M. Koomen, Inna V. Fedorenko, Jobin K. John,Hensin Tsao,Keith T. Flaherty, Vernon K. Sondak,Jane L. Messina,Elena B. Pasquale, Alejandro Villagra,Uma N. Rao,John M. Kirkwood, Friedegund Meier,Sarah Sloot,Geoffrey T. Gibney,Darrin Stuart, Hussein Tawbi,Keiran S.M. Smalley
crossref(2023)
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作者统计
#Papers: 267
#Citation: 19307
H-Index: 70
G-Index: 135
Sociability: 7
Diversity: 0
Activity: 1
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