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The gut microbiota is emerging as an important modulator of brain function and behavior, as several recent discoveries reveal substantial effects of the microbiome on neurophysiology, neurogenesis, blood brain barrier permeability, neuroimmunity, brain gene expression and animal behavior. Despite these findings supporting a “microbiome-gut-brain axis”, the molecular and cellular mechanisms that underlie interactions between the gut microbiota and brain remain poorly understood. To uncover these, the Hsiao laboratory is mining the human microbiota for microbial modulators of host neuroactive molecules, investigating the impact of microbiota-immune system interactions on neurodevelopment and examining the microbiome as an interface between gene-environment interactions in neurological diseases. We aim to dissect biological circuits for communication between the gut microbiota and nervous system, toward understanding fundamental biological pathways that influence brain and behavior. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?
The gut microbiota is emerging as an important modulator of brain function and behavior, as several recent discoveries reveal substantial effects of the microbiome on neurophysiology, neurogenesis, blood brain barrier permeability, neuroimmunity, brain gene expression and animal behavior. Despite these findings supporting a “microbiome-gut-brain axis”, the molecular and cellular mechanisms that underlie interactions between the gut microbiota and brain remain poorly understood. To uncover these, the Hsiao laboratory is mining the human microbiota for microbial modulators of host neuroactive molecules, investigating the impact of microbiota-immune system interactions on neurodevelopment and examining the microbiome as an interface between gene-environment interactions in neurological diseases. We aim to dissect biological circuits for communication between the gut microbiota and nervous system, toward understanding fundamental biological pathways that influence brain and behavior. Situated at the interface of neurobiology, immunology and microbiology, we are using integrative systems approaches to study fundamental questions in biology: What are the effects of the microbiota on the nervous system? How do resident microbes communicate with the nervous system? Which individual species or communities confer particular functional effects? How do microbe-nervous system interactions impact health and disease? What, if any, are the potential evolutionary benefits for microbes to interact with the nervous system? Can rational modification of the microbiota be used to treat symptoms of neurological diseases?
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论文共 102 篇作者统计合作学者相似作者
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Elena J. Coley-O’Rourke,Gregory R. Lum,Geoffrey N. Pronovost,Ezgi Özcan,Kristie B. Yu,Janet McDermott, Anna Chakhoyan, Eliza Goldman,Helen E. Vuong,Jorge Paramo,Alison Chu,Kara L. Calkins,Elaine Y. Hsiao
biorxiv(2024)
BIOLOGICAL PSYCHIATRYno. 4 (2024): 298-299
Kristie B. Yu,Celine Son, Anisha Chandra,Jorge Paramo, Anna Novoselov,Ezgi Özcan,Sabeen A. Kazmi,Gregory R. Lum, Arlene Lopez-Romero,Jonathan B. Lynch,Elaine Y. Hsiao
bioRxiv the preprint server for biology (2024)
Ezgi Özcan,Kristie B Yu, Lyna Dinh,Gregory R Lum, Katie Lau, Jessie Hsu, Mariana Arino,Jorge Paramo, Arlene Lopez-Romero,Elaine Y Hsiao
Current developments in nutrition (2024): 103439-103439
Annals of the New York Academy of Sciencesno. 1 (2023): 10-16
Nature communicationsno. 1 (2023)
Kelly G. Jameson,Sabeen A. Kazmi,Celine Son, Donya Mazdeyasnan, Emma Leshan,Helen E. Vuong,Jorge Paramo, Arlene Lopez-Romero, Long Yang,Felix E. Schweizer,Elaine Y. Hsiao
bioRxiv the preprint server for biology (2023)
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#Papers: 102
#Citation: 12413
H-Index: 31
G-Index: 102
Sociability: 6
Diversity: 0
Activity: 1
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