基本信息
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The overall goals of the Laboratory of Cardiovascular Science are (1) to identify age-associated changes that occur within the cardiovascular system and to determine the mechanisms for these changes; (2) to study myocardial structure and function and to determine how age interacts with chronic disease states to alter function; (3) to study basic mechanisms in excitation-contraction coupling and how these are modulated by surface receptor signaling pathways in cardiac muscle; (4) to determine the chemical nature and sequence of intermediate reactions controlling the movement of ions through ionic channels and pumps present in myocardium, and how these are affected by aging and disease; (5) to determine mechanisms that govern neuro-hormonal behavioral aspects of hypertension; (6) to determine mechanisms of normal and abnormal function of vascular smooth muscle and endothelial cells; and (7) to establish the potentials and limitations of new therapeutic approaches such as gene transfer techniques. In meeting these objectives, studies are performed in human volunteers, intact animals, isolated heart and vascular tissues, isolated cardiac and vascular cells, and subcellular organelles.
Research Interests
Papers共 1501 篇Author StatisticsCo-AuthorSimilar Experts
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期刊级别
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AJP Heart and Circulatory Physiologyno. 2 (2024): H509-H517
GeroSciencepp.1-20, (2024)
BIOPHYSICAL JOURNALno. 3 (2024): 383A-383A
Frontiers in epidemiology (2024): 1295209-1295209
Alexander V Maltsev, Valeria Ventura Subirachs, Oliver Monfredi, Magdalena Juhaszova, Pooja Ajay Warrier, Shardul Rakshit,Syevda Tagirova,Anna V Maltsev,Michael D Stern,Edward G Lakatta,Victor A Maltsev
biorxiv(2024)
GeroScienceno. 5 (2024): 5085-5101
Jacob M. Keaton,Zoha Kamali,Tian Xie,Ahmad Vaez,Ariel Williams,Slavina B. Goleva,Alireza Ani,Evangelos Evangelou,Jacklyn N. Hellwege,Loic Yengo,William J. Young,Matthew Traylor,Ayush Giri,Zhili Zheng,Jian Zeng,Daniel I. Chasman,Andrew P. Morris,Mark J. Caulfield,Shih-Jen Hwang,Jaspal S. Kooner,David Conen,John R. Attia,Alanna C. Morrison,Ruth J. F. Loos,Kati Kristiansson,Reinhold Schmidt,Andrew A. Hicks,Peter P. Pramstaller,Christopher P. Nelson,Nilesh J. Samani,Lorenz Risch,Ulf Gyllensten,Olle Melander,Harriette Riese,James F. Wilson,Harry Campbell,Stephen S. Rich,Bruce M. Psaty,Yingchang Lu,Jerome I. Rotter,Xiuqing Guo,Kenneth M. Rice,Peter Vollenweider,Johan Sundstrom,Claudia Langenberg,Martin D. Tobin,Vilmantas Giedraitis,Jian'an Luan,Jaakko Tuomilehto,Zoltan Kutalik,Samuli Ripatti,Veikko Salomaa,Giorgia Girotto,Stella Trompet,J. Wouter Jukema,Pim van der Harst,Paul M. Ridker,Franco Giulianini,Veronique Vitart,Anuj Goel,Hugh Watkins,Sarah E. Harris,Ian J. Deary,Peter J. van der Most,Albertine J. Oldehinkel,Bernard D. Keavney,Caroline Hayward,Archie Campbell,Michael Boehnke,Laura J. Scott,Thibaud Boutin,Chrysovalanto Mamasoula,Marjo-Riitta Jarvelin,Annette Peters,Christian Gieger,Edward G. Lakatta,Francesco Cucca,Jennie Hui,Paul Knekt,Stefan Enroth,Martin H. De Borst,Ozren Polasek,Maria Pina Concas,Eulalia Catamo,Massimiliano Cocca,Ruifang Li-Gao,Edith Hofer,Helena Schmidt,Beatrice Spedicati,Melanie Waldenberger,David P. Strachan,Maris Laan,Alexander Teumer,Marcus Dorr,Vilmundur Gudnason,James P. Cook,Daniela Ruggiero,Ivana Kolcic,Eric Boerwinkle,Michela Traglia,Terho Lehtimaki,Olli T. Raitakari,Andrew D. Johnson,Christopher Newton-Cheh,Morris J. Brown,Anna F. Dominiczak,Peter J. Sever,Neil Poulter,John C. Chambers,Roberto Elosua,David Siscovick,Tonu Esko,Andres Metspalu,Rona J. Strawbridge,Markku Laakso,Anders Hamsten,Jouke-Jan Hottenga,Eco de Geus,Andrew D. Morris,Colin N. A. Palmer,Ilja M. Nolte,Yuri Milaneschi,Jonathan Marten,Alan Wright,Eleftheria Zeggini, Joanna M. M. Howson,Christopher J. O'Donnell,Tim Spector,Mike A. Nalls,Eleanor M. Simonsick,Yongmei Liu,Cornelia M. van Duijn,Adam S. Butterworth,John N. Danesh,Cristina Menni,Nicholas J. Wareham,Kay-Tee Khaw,Yan V. Sun,Peter W. F. Wilson,Kelly Cho,Peter M. Visscher,Joshua C. Denny,Daniel Levy,Todd L. Edwards,Patricia B. Munroe,Harold Snieder,Helen R. Warren
NATURE GENETICS (2024)
BIOPHYSICAL JOURNALno. 3 (2024): 385A-386A
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Author Statistics
#Papers: 1508
#Citation: 101627
H-Index: 153
G-Index: 290
Sociability: 9
Diversity: 4
Activity: 124
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