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The Jorgensen laboratory is identifying the proteins that function at the synapse to release and recycle synaptic vesicles. To identify these molecules, we have undertaken a genetic analysis of neurotransmission in the nematode Caenorhabditis elegans. C. elegans is particularly advantageous for such studies for several reasons: First, mutants with defective synapses are viable and can be studied as adults. Second, we can select for mutants with defective neurotransmission using drug resistance screens. Third, we can characterize mutant synapses at the ultrastructural and electrophysiological levels. So far the lab has identified over 30 genes that are required for normal synaptic transmission. Some of these genes are required for synaptic vesicle exocytosis and some are required for synaptic vesicle endocytosis. The precise function of these proteins is being determined using electophysiological, biochemical, fluorescence and electron microscopic techniques.
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M Wayne Davis,Erik M Jorgensen
CELL REPORTSno. 5 (2024)
IEEE TRANSACTIONS ON ANTENNAS AND PROPAGATIONno. 5 (2024): 4454-4464
BIO-PROTOCOLno. 16 (2024)
ELIFE (2024)
Sanduni I. Fernando,Jason T. Martineau,M. Wayne Davis, Andrew R. Erickson, Benjamin C. Bromley,Erik M. Jorgensen,Jordan M. Gerton
Three-Dimensional and Multidimensional Microscopy Image Acquisition and Processing XXXI (2024)
Abbas Ali Qayyum,Mette Mouridsen,Brian Nilsson,Ida Gustafsson,Morten Schou,Olav Wendelboe Nielsen,Jens Dahlgaard Hove,Anders Bruun Mathiasen,Erik Jorgensen,Steffen Helqvist,Francis Richard Joshi,Ellen Monsted Johansen,Bjarke Follin,Morten Juhl,Lisbeth Drozd Hojgaard,Mandana Haack-Sorensen,Annette Ekblond,Jens Kastrup
2023 17TH EUROPEAN CONFERENCE ON ANTENNAS AND PROPAGATION, EUCAP (2023)
2023 INTERNATIONAL CONFERENCE ON ELECTROMAGNETICS IN ADVANCED APPLICATIONS, ICEAApp.277-279, (2023)
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#Papers: 600
#Citation: 33522
H-Index: 91
G-Index: 168
Sociability: 8
Diversity: 4
Activity: 33
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