Edward John Wherry III (known professionally as John Wherry) is an American immunologist.
Wherry's research has focused on the field of T cell exhaustion, elucidating mechanisms that attenuate T cell responses during chronic infections and cancer. His discoveries include characterizing several immunological checkpoints and T cell states that can be targeted to re-invigorate exhausted T cells. Wherry's lab has played a prominent role in understanding the concept of human immune health using high-dimensional, integrative, translational immunology approaches.