Dr. Spitz’s laboratory is involved with the study of free radicals and oxidative stress in biology and medicine. Ongoing projects include the study of phenotypic changes associated with oxidative stress-resistant mammalian cell lines, oxidative stress induced by PCB exposure, nitric oxide toxicology, molecular mechanisms of resistance to oxidative stress, molecular imaging of responses to cancer therapy, redox regulation of the cell cycle, redox regulation of signal transduction and gene expression as well as metabolic oxidative stress associated with glucose deprivation-induced cytotoxicity in human tumor cells. Dr. Spitz’s long term goal is to use a basic science understanding of mechanisms associated with free radical toxicology to elucidate novel methods for manipulating clinically significant outcomes in areas of medicine relevant to cancer biology and degenerative diseases associated with aging.