His research interests, grant support and publications have been focused on lung cancer, and specifically proteomic and expression array signature development, lung cancer genetics, cancer immunotherapy, tumor-associated immunosuppression mechanisms. Recent research directions include development of molecular biomarkers to guide patient management and therapy, and molecular profiling of lung cancers and preneoplasias to guide the development of novel therapeutics, especially using mass spectrometry-based proteomics. He has over 200 peer-reviewed publications, books and review articles, has served on several NCI grant review panels, including the clinical program project parent committee, and has continuous NCI funding since early in his career. He has served on the Board of Scientific Counselors for the NCI, and is currently Chair of the Lung Biology subcommittee for the Eastern Cooperative Oncology Group and Past President of the International Association for the Study of Lung Cancer (IASLC).