Dan has won several awards for his work and is a member of the National Academy of Medicine. The Geschwind laboratory pioneered the application of systems biology methods in neurologic and psychiatric disease, with a focus on autism spectrum disorders (ASD) and neurodegenerative conditions. The laboratory showed that gene co-expression has a reproducible network structure that can be used to understand neurobiological mechanisms in health and disease, and led the first studies to define the molecular pathology of autism and several other major psychiatric disorders. We demonstrated the utility of using gene network approaches to discover new pathways involved in neurodegeneration and new approaches to facilitate neural regeneration. Recognizing the importance of tissue specific gene regulation in disease susceptibility, the laboratory has developed several resources focusing on genetic and epigenetic regulation during human brain development to inform interpretation of genetic variation associated with neuropsychiatric and neurodevelopment disorders. We also have made significant contributions to defining the genetic basis of autism, starting with the development (in collaboration with the Cure Autism Now Foundation) of the Autism Genetic Resource Exchange an open shared resource for autism genetic studies, now a program of Autism Speaks