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个人简介
Professor David Sansom
Professor of Transplant Immunology
About
Research in the Sansom lab focusses on fundamental aspects of how immune checkpoints influence T cell activation decisions.
Research summary
The activation of T cells is a critical part of the immune response. Without effective T cell responses we could not fight infections properly and vaccines would not work. However, T cell responses can also be dangerous to our bodies and it is clear that diseases such as rheumatoid arthritis and type-I diabetes as well as rejection of transplanted organs all involve unwanted T cell responses.
My laboratory works on fundamental aspects of how T cells determine whether to make immune responses or not. In particular we focus on the interplay between two receptors on T cells, CD28 and CTLA-4 and their binding partners, CD80 and CD86. Our work on the underlying molecular and cellular mechanisms has led to advances in understanding how the CD28/CTLA-4 system functions and this knowledge has been used to develop tests of human T cell function and regulatory T cell suppression.
Professor of Transplant Immunology
About
Research in the Sansom lab focusses on fundamental aspects of how immune checkpoints influence T cell activation decisions.
Research summary
The activation of T cells is a critical part of the immune response. Without effective T cell responses we could not fight infections properly and vaccines would not work. However, T cell responses can also be dangerous to our bodies and it is clear that diseases such as rheumatoid arthritis and type-I diabetes as well as rejection of transplanted organs all involve unwanted T cell responses.
My laboratory works on fundamental aspects of how T cells determine whether to make immune responses or not. In particular we focus on the interplay between two receptors on T cells, CD28 and CTLA-4 and their binding partners, CD80 and CD86. Our work on the underlying molecular and cellular mechanisms has led to advances in understanding how the CD28/CTLA-4 system functions and this knowledge has been used to develop tests of human T cell function and regulatory T cell suppression.
研究兴趣
论文共 105 篇作者统计合作学者相似作者
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Christina J.F. Courreges, Elizabeth C.M. Davenport,Benoit Bilanges, Elena Rebollo-Gomez,Jens Hukelmann,Priya Schoenfelder,James R. Edgar,David Sansom,Cheryl Scudamore,Rahul Roychudhuri,Oliver A. Garden,Bart Vanhaesebroeck,Klaus Okkenhaug
biorxiv(2024)
Thomas Andrew Fox,Benjamin Christopher Houghton,Lina Petersone,Erin Waters,Natalie Mona Edner, Alex McKenna,Olivier Preham,Claudia Hinze,Cayman Williams,Adriana Silva de Albuquerque,Alan Kennedy,Anne Maria Pesenacker,Pietro Genovese,Lucy Sarah Kate Walker,Siobhan Oisin Burns,David Michael Sansom,Claire Booth,Emma Catherine Morris
Alan Kennedy,Erin Waters,Behzad Rowshanravan,Claudia Hinze,Cayman Williams,Daniel Janman,Thomas A. Fox,Claire Booth,Anne M. Pesenacker,Neil Halliday,Blagoje Soskic,Satdip Kaur,Omar S. Qureshi,Emma C. Morris,Shinji Ikemizu,Christopher Paluch,Jiandong Huo,Simon J. Davis,Emmanuel Boucrot,Lucy S. K. Walker,David M. Sansom
James E. D. Thaventhiran,Hana Lango Allen,Oliver S. Burren,William Rae,Daniel Greene,Emily Staples,Zinan Zhang,James H. R. Farmery,Ilenia Simeoni,Elizabeth Rivers,Jesmeen Maimaris,Christopher J. Penkett, Jonathan Stephens,Sri V. V. Deevi,Alba Sanchis-Juan,Nicholas S. Gleadall,Moira J. Thomas,Ravishankar B. Sargur,Pavels Gordins,Helen E. Baxendale, Matthew Brown,Paul Tuijnenburg,Austen Worth,Steven Hanson,Rachel J. Linger,Matthew S. Buckland,Paula J. Rayner-Matthews,Kimberly C. Gilmour,Crina Samarghitean,Suranjith L. Seneviratne,David M. Sansom,Andy G. Lynch,Karyn Megy,Eva Ellinghaus,David Ellinghaus,Silje F. Jorgensen,Tom H. Karlsen,Kathleen E. Stirrups,Antony J. Cutler,Dinakantha S. Kumararatne,Anita Chandra,J. David M. Edgar,Archana Herwadkar,Nichola Cooper,Sofia Grigoriadou,Aarnoud P. Huissoon,Sarah Goddard,Stephen Jolles,Catharina Schuetz,Felix Boschann
James E. D. Thaventhiran,Hana Lango Allen,Oliver S. Burren,William Rae,Daniel Greene,Emily Staples,Zinan Zhang,James H. R. Farmery,Ilenia Simeoni,Elizabeth Rivers,Jesmeen Maimaris,Christopher J. Penkett,Jonathan Stephens,Sri V. V. Deevi,Alba Sanchis-Juan,Nicholas S. Gleadall,Moira J. Thomas,Ravishankar B. Sargur,Pavels Gordins,Helen E. Baxendale,Matthew Brown,Paul Tuijnenburg,Austen Worth,Steven Hanson,Rachel J. Linger,Matthew S. Buckland,Paula J. Rayner-Matthews,Kimberly C. Gilmour,Crina Samarghitean,Suranjith L. Seneviratne,David M. Sansom,Andy G. Lynch,Karyn Megy,Eva Ellinghaus,David Ellinghaus,Silje F. Jorgensen,Tom H. Karlsen,Kathleen E. Stirrups,Antony J. Cutler,Dinakantha S. Kumararatne,Anita Chandra,J. David M. Edgar,Archana Herwadkar,Nichola Cooper,Sofia Grigoriadou,Aarnoud P. Huissoon,Sarah Goddard,Stephen Jolles,Catharina Schuetz,Felix Boschann,Stephen Abbs,Paul A. Lyons,Matthew E. Hurles,Sinisa Savic,Siobhan O. Burns,Taco W. Kuijpers,Ernest Turro,Willem H. Ouwehand,Adrian J. Thrasher, Kenneth G. C. Smith
Natureno. 7819 (2020): E2-E2
Nina K. Serwas,Birgit Hoeger,Rico C. Ardy, Sigrun V. Stulz,Zhenhua Sui,Nima Memaran,Marie Meeths,Ana Krolo,Özlem Yüce Petronczki,Laurène Pfajfer,Tie Z. Hou,Neil Halliday,Elisangela Santos-Valente,Artem Kalinichenko,Alan Kennedy,Emily M. Mace,Malini Mukherjee,Bianca Tesi,Anna Schrempf,Winfried F. Pickl,Joanna I. Loizou,Renate Kain,Bettina Bidmon-Fliegenschnee,Jean-Nicolas Schickel,Salomé Glauzy,Jakob Huemer,Wojciech Garncarz,Elisabeth Salzer, Iro Pierides,Ivan Bilic,Jens Thiel,Peter Priftakis,Pinaki P. Banerjee,Elisabeth Förster-Waldl,David Medgyesi,Wolf-Dietrich Huber,Jordan S. Orange,Eric Meffre,David M. Sansom,Yenan T. Bryceson,Amnon Altman,Kaan Boztug
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作者统计
#Papers: 106
#Citation: 7889
H-Index: 42
G-Index: 88
Sociability: 6
Diversity: 3
Activity: 23
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