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个人简介
My work on antitrypsin deficiency led to work to identify genetic and protein biomarkers for the stratification of individuals with chronic obstructive pulmonary disease (COPD). I was the founder and co-lead PI of the International COPD Genetics Network that demonstrated that airway wall thickening and emphysema make independent contributions to airflow obstruction in COPD (Am. J. Resp. Crit. Care Med. 2008;178:500-5) and that was used to undertake the first genome wide association study (GWAS) in COPD. This identified single nucleotide polymorphisms (SNPs) in the nicotinic acetylcholine receptor/IREB2, HHIP and FAM13A (PLoS Genet. 2009;5:e1000421; Nat. Genet. 2010;42:200-202). These findings have now been replicated in multiple other cohorts of individuals with COPD by different investigators. The results help to explain why some people who smoke develop lung disease whilst others do not and may provide targets for new therapies for this condition. I served on the steering committee of the ECLIPSE study that recruited approximately 3000 individuals from 42 centres to identify novel endpoints for COPD. We showed that exacerbations are a stable phenotype in COPD (N. Engl. J. Med. 2010;363;1128- 1138) and that C-16 predicts decline in FEV1 (N. Engl. J. Med 2011;365:1184-1192). Exacerbations are now routinely used as an endpoint for clinical trials of new therapies for COPD.
研究兴趣
论文共 794 篇作者统计合作学者相似作者
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Methods in molecular biology (Clifton, N.J.) (2024): 41-55
Anandini Suri,Zidong Zhang,Brent Neuschwander-Tetri,David A Lomas,Nina Heyer-Chauhan,Keith Burling,Rohit Loomba,David A Brenner, Rosemary Nagy, Andrew Wilson,Danielle Carpenter, Keith Blomenkamp, Jeffrey Teckman
Liver international official journal of the International Association for the Study of the Liver (2024)
Gastro hep advancesno. 6 (2024): 842-850
The FEBS journalno. 13 (2024): 2937-2954
Deniz Kent,Soon Seng Ng,Adam M Syanda,Payam Khoshkenar,Riccardo Ronzoni,Chao Zheng Li,Marina Zieger, Cindy Greer,Stephanie Hatch,Joe Segal,Samuel J I Blackford,Yu Ri Im,Vivek Chowdary,Taylor Ismaili,Davide Danovi, Patrick A Lewis,James A Irving,Sunil Sahdeo,David A Lomas,Daniel Ebner, Christian Mueller,S Tamir Rashid
Hepatology (Baltimore, Md.) (2024)
ACTA PHYSIOLOGICA (2023): 9-9
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Figshare (2023)
Figshare (2023)
HEPATOLOGYno. 5 (2023): E118-E118
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作者统计
#Papers: 785
#Citation: 48400
H-Index: 107
G-Index: 201
Sociability: 8
Diversity: 0
Activity: 2
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