基本信息
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Bio
We focus on the modifier ubiquitin, a small protein that modifies other proteins in a variety of distinct ways, known as the ‘ubiquitin code’.
Ubiquitination most commonly leads to destruction of the modified protein, but can also change its activation, interactions or localisation. Much of our work aims to enable studies of ubiquitin signals.
A biological focus of the lab are deubiquitinases (DUBs) that remove ubiquitin from proteins. Using structural biology and biophysics, we have unraveled many mechanistic and regulatory principles of how DUBs cleave ubiquitin modifications.
Using preclinical models and in collaboration with human geneticists, we ascribe cellular and physiological function to select enzymes. Finally, in collaboration with industry, we are developing the first enzyme-specific DUB inhibitors, which may become new treatments for cancer and neurodegeneration.
Research Interests
Papers共 207 篇Author StatisticsCo-AuthorSimilar Experts
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Sophia Davidson,Yuri Shibata, Sophie Collard, Hongyu Zheng,Klara Kong, June M. Sun,Pawat Laohamonthonkul, Anthony Cerra,Tobias Kratina,Margaret W. Y. Li,Carolyn Russell, Anna van Beek,Edwin P. Kirk,Rebecca Walsh,Jubran Alqanatish,Abdullah Almojali, Wafaa Alsuwairi,Abdulrahman Alrasheed,Najoua Lalaoui,Paul E. Gray,David Komander,Seth L. Masters
JOURNAL OF EXPERIMENTAL MEDICINEno. 6 (2024)
biorxiv(2024)
Xinyu Wu,Margareta Go,Julie V. Nguyen,Nathan W. Kuchel,Bernadine G. C. Lu, Kathleen Zeglinski,Kym N. Lowes,Dale J. Calleja, Jeffrey P. Mitchell,Guillaume Lessene,David Komander,Matthew E. Call,Melissa J. Call
Autophagyno. 11 (2024): 2596-2597
Giang Thanh Nguyen-Dien,Brendan Townsend, Prajakta Gosavi Kulkarni,Keri-Lyn Kozul, Soo Siang Ooi, Denaye N. Eldershaw,Saroja Weeratunga,Meihan Liu,Mathew J. K. Jones,S. Sean Millard,Dominic C. H. Ng,Michele Pagano,Alexis Bonfim-Melo, Tobias Schneider,David Komander,Michael Lazarou,Brett M. Collins,Julia K. Pagan
EMBO REPORTSno. 8 (2024): 3324-3347
David Komander,Marcel Doerflinger,Stefanie M. Bader,Dale Calleja, Shane Devine, Nathan Kuchel,Bernadine Lu, Xinyu Wu, Richard Birkinshaw, Reet Bhandari, Katie Loi, Rohan Volpe, Yelena Khakham, Amanda Au, Timothy Blackmore,Liana Mackiewicz, Merle Dayton,Jan Schaefer, Lena Scherer, Angus Stock,James Cooney, Kael Schoffer, Ana Maluenda, Elizabeth Kleeman, Kathryn Davidson,Cody Allison, Gregor Ebert, Gong Chen,Theresa Klemm, Ueli Nachbur, Smitha Georgy,Peter Czabotar, Anthony Hannan, Tracy Putoczki,Maria Tanzer,Marc Pellegrini,Bernhard Lechtenberg,Susan Charman,Melissa Call,Jeffrey Mitchell,Kym Lowes,Guillaume Lessene
crossref(2024)
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Author Statistics
#Papers: 208
#Citation: 27010
H-Index: 73
G-Index: 164
Sociability: 8
Diversity: 0
Activity: 1
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