Dr. Holtgrave's research has focused on the effectiveness and cost-effectiveness of a variety of HIV prevention and care interventions (including the provision of housing as a structural HIV/AIDS intervention), and the relationship of the findings of these studies to HIV prevention policy making. His scholarly works include over 325 professional publications. He has served on an Institute of Medicine panel charged with recommending methods to improve the public financing and delivery of HIV care in the United States. Dr. Holtgrave has also previously served as the Director of the Division of HIV/AIDS Prevention -- Intervention Research & Support at the US Federal Centers for Disease Control and Prevention (CDC). During President Barack Obama's Administration, Dr. Holtgrave served as a member and then Vice-Chair of the Presidential Advisory Council on HIV/AIDS (PACHA). Most recently, Dr. Holtgrave has worked intensively on COVID-19 projects conducted in partnership with the New York State Department of Health. This worked has focused on COVID-19 treatment, prevention, epidemiology, and the addressing of racial and ethnic health disparities.