David J. Dilworth

My research focuses on the epigenetic determinants of cancer. In particular, I am interested in how transcriptional networks that drive the proliferation of cancer cells are established and maintained through the post-translational modification of chromatin. During my Ph.D., under the supervision of Dr. Christopher J. Nelson at the University of Victoria, I explored a noncovalent chromatin modification called proline isomerization. This research identified several novel functions for the nuclear proline isomerase FKBP25 in the maintenance of genomic stability. Recently, I have taken up a postdoctoral position at the Structural Genomics Consortium, where I will be characterizing chemical probes (ie. precision inhibitors) that target epigenetic pathways relevant to human disease.