Research Interests My laboratory uses structural and biophysical techniques to probe protein-protein and protein-DNA interactions critical to the formation of macromolecular complexes. Over the past several years, we have been studying the Nucleosome Remodeling and Deacetylase (NuRD) complex responsible for recognizing methylated DNA and silencing expression of the associated genes. Our focus has been to understand how a key component of this complex, the methyl-cytosine binding domain protein 2 (MBD2), binds DNA and recruits the rest of NuRD.